DNase Sda1 Allows Invasive M1T1 Group A Streptococcus to Prevent TLR9-Dependent Recognition

Group A Streptococcus (GAS) has developed a broad arsenal of virulence factors that serve to circumvent host defense mechanisms. The virulence factor DNase Sda1 of the hyperinvasive M1T1 GAS clone degrades DNA-based neutrophil extracellular traps allowing GAS to escape extracellular killing. TLR9 is...

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Detalles Bibliográficos
Autores principales: Uchiyama, Satoshi, Andreoni, Federica, Schuepbach, Reto A., Nizet, Victor, Zinkernagel, Annelies S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375267/
https://www.ncbi.nlm.nih.gov/pubmed/22719247
http://dx.doi.org/10.1371/journal.ppat.1002736

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375267/
https://www.ncbi.nlm.nih.gov/pubmed/22719247
http://dx.doi.org/10.1371/journal.ppat.1002736

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