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DNase Sda1 Allows Invasive M1T1 Group A Streptococcus to Prevent TLR9-Dependent Recognition
Group A Streptococcus (GAS) has developed a broad arsenal of virulence factors that serve to circumvent host defense mechanisms. The virulence factor DNase Sda1 of the hyperinvasive M1T1 GAS clone degrades DNA-based neutrophil extracellular traps allowing GAS to escape extracellular killing. TLR9 is...
Autores principales: | Uchiyama, Satoshi, Andreoni, Federica, Schuepbach, Reto A., Nizet, Victor, Zinkernagel, Annelies S. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375267/ https://www.ncbi.nlm.nih.gov/pubmed/22719247 http://dx.doi.org/10.1371/journal.ppat.1002736 |
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