Cargando…
Axonal degeneration as a therapeutic target in the CNS
Degeneration of the axon is an important step in the pathomechanism of traumatic, inflammatory and degenerative neurological diseases. Increasing evidence suggests that axonal degeneration occurs early in the course of these diseases and therefore represents a promising target for future therapeutic...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer-Verlag
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375418/ https://www.ncbi.nlm.nih.gov/pubmed/22392734 http://dx.doi.org/10.1007/s00441-012-1362-3 |
_version_ | 1782235755401183232 |
---|---|
author | Lingor, Paul Koch, Jan C. Tönges, Lars Bähr, Mathias |
author_facet | Lingor, Paul Koch, Jan C. Tönges, Lars Bähr, Mathias |
author_sort | Lingor, Paul |
collection | PubMed |
description | Degeneration of the axon is an important step in the pathomechanism of traumatic, inflammatory and degenerative neurological diseases. Increasing evidence suggests that axonal degeneration occurs early in the course of these diseases and therefore represents a promising target for future therapeutic strategies. We review the evidence for axonal destruction from pathological findings and animal models with particular emphasis on neurodegenerative and neurotraumatic disorders. We discuss the basic morphological and temporal modalities of axonal degeneration (acute, chronic and focal axonal degeneration and Wallerian degeneration). Based on the mechanistic concepts, we then delineate in detail the major molecular mechanisms that underlie the degenerative cascade, such as calcium influx, axonal transport, protein aggregation and autophagy. We finally concentrate on putative therapeutic targets based on the mechanistic prerequisites. |
format | Online Article Text |
id | pubmed-3375418 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-33754182012-06-18 Axonal degeneration as a therapeutic target in the CNS Lingor, Paul Koch, Jan C. Tönges, Lars Bähr, Mathias Cell Tissue Res Review Degeneration of the axon is an important step in the pathomechanism of traumatic, inflammatory and degenerative neurological diseases. Increasing evidence suggests that axonal degeneration occurs early in the course of these diseases and therefore represents a promising target for future therapeutic strategies. We review the evidence for axonal destruction from pathological findings and animal models with particular emphasis on neurodegenerative and neurotraumatic disorders. We discuss the basic morphological and temporal modalities of axonal degeneration (acute, chronic and focal axonal degeneration and Wallerian degeneration). Based on the mechanistic concepts, we then delineate in detail the major molecular mechanisms that underlie the degenerative cascade, such as calcium influx, axonal transport, protein aggregation and autophagy. We finally concentrate on putative therapeutic targets based on the mechanistic prerequisites. Springer-Verlag 2012-03-06 2012 /pmc/articles/PMC3375418/ /pubmed/22392734 http://dx.doi.org/10.1007/s00441-012-1362-3 Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Review Lingor, Paul Koch, Jan C. Tönges, Lars Bähr, Mathias Axonal degeneration as a therapeutic target in the CNS |
title | Axonal degeneration as a therapeutic target in the CNS |
title_full | Axonal degeneration as a therapeutic target in the CNS |
title_fullStr | Axonal degeneration as a therapeutic target in the CNS |
title_full_unstemmed | Axonal degeneration as a therapeutic target in the CNS |
title_short | Axonal degeneration as a therapeutic target in the CNS |
title_sort | axonal degeneration as a therapeutic target in the cns |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375418/ https://www.ncbi.nlm.nih.gov/pubmed/22392734 http://dx.doi.org/10.1007/s00441-012-1362-3 |
work_keys_str_mv | AT lingorpaul axonaldegenerationasatherapeutictargetinthecns AT kochjanc axonaldegenerationasatherapeutictargetinthecns AT tongeslars axonaldegenerationasatherapeutictargetinthecns AT bahrmathias axonaldegenerationasatherapeutictargetinthecns |