Inhibition of Autophagy Rescues Palmitic Acid-induced Necroptosis of Endothelial Cells

Accumulation of palmitic acid (PA) in cells from nonadipose tissues is known to induce lipotoxicity resulting in cellular dysfunction and death. The exact molecular pathways of PA-induced cell death are still mysterious. Here, we show that PA triggers autophagy, which did not counteract but in contr...

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Detalles Bibliográficos
Autores principales: Khan, Muhammad Jadoon, Rizwan Alam, Muhammad, Waldeck-Weiermair, Markus, Karsten, Felix, Groschner, Lukas, Riederer, Monika, Hallström, Seth, Rockenfeller, Patrick, Konya, Viktoria, Heinemann, Akos, Madeo, Frank, Graier, Wolfgang F., Malli, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375534/
https://www.ncbi.nlm.nih.gov/pubmed/22556413
http://dx.doi.org/10.1074/jbc.M111.319129

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375534/
https://www.ncbi.nlm.nih.gov/pubmed/22556413
http://dx.doi.org/10.1074/jbc.M111.319129

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