Cargando…
Fine mapping and conditional analysis identify a new mutation in the autoimmunity susceptibility gene BLK that leads to reduced half-life of the BLK protein
OBJECTIVES: To perform fine mapping of the autoimmunity susceptibility gene BLK and identify functional variants involved in systemic lupus erythematosus (SLE). METHODS: Genotyping of 1163 European SLE patients and 1482 controls and imputation were performed covering the BLK gene with 158 single-nuc...
Autores principales: | Delgado-Vega, Angélica M, Dozmorov, Mikhail G, Quirós, Manuel Bernal, Wu, Ying-Yu, Martínez-García, Belén, Kozyrev, Sergey V, Frostegård, Johan, Truedsson, Lennart, de Ramón, Enrique, González-Escribano, María F, Ortego-Centeno, Norberto, Pons-Estel, Bernardo A, D'Alfonso, Sandra, Sebastiani, Gian Domenico, Witte, Torsten, Lauwerys, Bernard R, Endreffy, Emoke, Kovács, László, Vasconcelos, Carlos, da Silva, Berta Martins, Wren, Jonathan D, Martin, Javier, Castillejo-López, Casimiro, Alarcón-Riquelme, Marta E |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Group
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375585/ https://www.ncbi.nlm.nih.gov/pubmed/22696686 http://dx.doi.org/10.1136/annrheumdis-2011-200987 |
Ejemplares similares
-
BANK1 and BLK Act through Phospholipase C Gamma 2 in B-Cell Signaling
por: Bernal-Quirós, Manuel, et al.
Publicado: (2013) -
IgA Vasculitis: Influence of CD40, BLK and BANK1 Gene Polymorphisms
por: Batista Liz, Joao Carlos, et al.
Publicado: (2022) -
BLK polymorphisms and expression level in neuromyelitis optica spectrum disorder
por: Yin, Bo‐Wen, et al.
Publicado: (2021) -
Mimicry of Pre–B Cell Receptor Signaling by Activation of the Tyrosine Kinase Blk
por: Tretter, Theresa, et al.
Publicado: (2003) -
The Effect of Inversion at 8p23 on BLK Association with Lupus in Caucasian Population
por: Namjou, Bahram, et al.
Publicado: (2014)