Interfacing medicinal chemistry with structural bioinformatics: implications for T box riboswitch RNA drug discovery

BACKGROUND: The T box riboswitch controls bacterial transcription by structurally responding to tRNA aminoacylation charging ratios. Knowledge of the thermodynamic stability difference between two competing structural elements within the riboswitch, the terminator and the antiterminator, is critical...

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Detalles Bibliográficos
Autores principales: Jentzsch, Franziska, Hines, Jennifer V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375634/
https://www.ncbi.nlm.nih.gov/pubmed/22536868
http://dx.doi.org/10.1186/1471-2105-13-S2-S5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375634/
https://www.ncbi.nlm.nih.gov/pubmed/22536868
http://dx.doi.org/10.1186/1471-2105-13-S2-S5

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