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Interfacing medicinal chemistry with structural bioinformatics: implications for T box riboswitch RNA drug discovery
BACKGROUND: The T box riboswitch controls bacterial transcription by structurally responding to tRNA aminoacylation charging ratios. Knowledge of the thermodynamic stability difference between two competing structural elements within the riboswitch, the terminator and the antiterminator, is critical...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375634/ https://www.ncbi.nlm.nih.gov/pubmed/22536868 http://dx.doi.org/10.1186/1471-2105-13-S2-S5 |