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Classical dendritic cells as a unique immune cell lineage
Despite the critical role of classical dendritic cells (cDCs) in the initiation of adaptive immune responses, the genetic and phenotypic definition of cDCs remains moot. Two new studies designate Zbtb46 as a novel transcription factor that is specifically expressed in all cDCs in both humans and mic...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Rockefeller University Press
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375637/ https://www.ncbi.nlm.nih.gov/pubmed/22665701 http://dx.doi.org/10.1084/jem.20121038 |
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author | Reizis, Boris |
author_facet | Reizis, Boris |
author_sort | Reizis, Boris |
collection | PubMed |
description | Despite the critical role of classical dendritic cells (cDCs) in the initiation of adaptive immune responses, the genetic and phenotypic definition of cDCs remains moot. Two new studies designate Zbtb46 as a novel transcription factor that is specifically expressed in all cDCs in both humans and mice. Although Zbtb46 appears dispensable for cDC development, its specific pattern of expression supports the notion that cDCs constitute a unique immune cell lineage. Furthermore, these two studies provide novel tools that will aid in the study of cDC progenitors, visualization of cDCs in vivo, and depletion of cDCs for functional analysis. |
format | Online Article Text |
id | pubmed-3375637 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-33756372012-12-04 Classical dendritic cells as a unique immune cell lineage Reizis, Boris J Exp Med Minireview Despite the critical role of classical dendritic cells (cDCs) in the initiation of adaptive immune responses, the genetic and phenotypic definition of cDCs remains moot. Two new studies designate Zbtb46 as a novel transcription factor that is specifically expressed in all cDCs in both humans and mice. Although Zbtb46 appears dispensable for cDC development, its specific pattern of expression supports the notion that cDCs constitute a unique immune cell lineage. Furthermore, these two studies provide novel tools that will aid in the study of cDC progenitors, visualization of cDCs in vivo, and depletion of cDCs for functional analysis. The Rockefeller University Press 2012-06-04 /pmc/articles/PMC3375637/ /pubmed/22665701 http://dx.doi.org/10.1084/jem.20121038 Text en © 2012 Reizis This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/). |
spellingShingle | Minireview Reizis, Boris Classical dendritic cells as a unique immune cell lineage |
title | Classical dendritic cells as a unique immune cell lineage |
title_full | Classical dendritic cells as a unique immune cell lineage |
title_fullStr | Classical dendritic cells as a unique immune cell lineage |
title_full_unstemmed | Classical dendritic cells as a unique immune cell lineage |
title_short | Classical dendritic cells as a unique immune cell lineage |
title_sort | classical dendritic cells as a unique immune cell lineage |
topic | Minireview |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375637/ https://www.ncbi.nlm.nih.gov/pubmed/22665701 http://dx.doi.org/10.1084/jem.20121038 |
work_keys_str_mv | AT reizisboris classicaldendriticcellsasauniqueimmunecelllineage |