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Toward Large-Scale Computational Fluid-Solid-Growth Models of Intracranial Aneurysms

Complementary advances in medical imaging, vascular biology, genetics, biomechanics, and computational methods promise to enable the development of mathematical models of the enlargement and possible rupture of intracranial aneurysms that can help inform clinical decisions. Nevertheless, this ultima...

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Detalles Bibliográficos
Autores principales: Di Achille, Paolo, Humphrey, Jay D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: YJBM 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375664/
https://www.ncbi.nlm.nih.gov/pubmed/22737050
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author Di Achille, Paolo
Humphrey, Jay D.
author_facet Di Achille, Paolo
Humphrey, Jay D.
author_sort Di Achille, Paolo
collection PubMed
description Complementary advances in medical imaging, vascular biology, genetics, biomechanics, and computational methods promise to enable the development of mathematical models of the enlargement and possible rupture of intracranial aneurysms that can help inform clinical decisions. Nevertheless, this ultimate goal is extremely challenging given the many diverse and complex factors that control the natural history of these lesions. As it should be expected, therefore, predictive models continue to develop in stages, with new advances incorporated as data and computational methods permit. In this paper, we submit that large-scale, patient-specific, fluid-solid interaction models of the entire circle of Willis and included intracranial aneurysm are both computationally tractable and necessary as a critical step toward fluid-solid-growth (FSG) models that can address the evolution of a lesion while incorporating information on the genetically and mechanobiologically determined microstructure of the wall.
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spelling pubmed-33756642012-06-25 Toward Large-Scale Computational Fluid-Solid-Growth Models of Intracranial Aneurysms Di Achille, Paolo Humphrey, Jay D. Yale J Biol Med Focus: Biomedical Engineering Complementary advances in medical imaging, vascular biology, genetics, biomechanics, and computational methods promise to enable the development of mathematical models of the enlargement and possible rupture of intracranial aneurysms that can help inform clinical decisions. Nevertheless, this ultimate goal is extremely challenging given the many diverse and complex factors that control the natural history of these lesions. As it should be expected, therefore, predictive models continue to develop in stages, with new advances incorporated as data and computational methods permit. In this paper, we submit that large-scale, patient-specific, fluid-solid interaction models of the entire circle of Willis and included intracranial aneurysm are both computationally tractable and necessary as a critical step toward fluid-solid-growth (FSG) models that can address the evolution of a lesion while incorporating information on the genetically and mechanobiologically determined microstructure of the wall. YJBM 2012-06-25 /pmc/articles/PMC3375664/ /pubmed/22737050 Text en Copyright ©2012, Yale Journal of Biology and Medicine https://creativecommons.org/licenses/by-nc/3.0/This is an open access article distributed under the terms of the Creative Commons CC BY-NC license, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited. You may not use the material for commercial purposes.
spellingShingle Focus: Biomedical Engineering
Di Achille, Paolo
Humphrey, Jay D.
Toward Large-Scale Computational Fluid-Solid-Growth Models of Intracranial Aneurysms
title Toward Large-Scale Computational Fluid-Solid-Growth Models of Intracranial Aneurysms
title_full Toward Large-Scale Computational Fluid-Solid-Growth Models of Intracranial Aneurysms
title_fullStr Toward Large-Scale Computational Fluid-Solid-Growth Models of Intracranial Aneurysms
title_full_unstemmed Toward Large-Scale Computational Fluid-Solid-Growth Models of Intracranial Aneurysms
title_short Toward Large-Scale Computational Fluid-Solid-Growth Models of Intracranial Aneurysms
title_sort toward large-scale computational fluid-solid-growth models of intracranial aneurysms
topic Focus: Biomedical Engineering
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375664/
https://www.ncbi.nlm.nih.gov/pubmed/22737050
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