Bone Marrow Involvement in a Patient with Alpha Heavychain Disease: Response to Tetracycline Treatment

A 28-year-old man from East Mediterranean area admitted with abdominal pain, weight loss and diarrhea. Barium x-ray studies showed segmentation, dilatation of bowel loops, mucosal folds thickening and delayed intestinal transit. Histological examination of biopsy specimens revealed villous atrophy a...

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Detalles Bibliográficos
Autores principales: Bolaman, Zahit, Yavasoglu, Irfan, Sargin, Gokhan, Kadikoylu, Gurhan, Doğer, Firuzan Kaçar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Università Cattolica del Sacro Cuore 2012
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375673/
https://www.ncbi.nlm.nih.gov/pubmed/22708049
http://dx.doi.org/10.4084/MJHID.2012.034
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author Bolaman, Zahit
Yavasoglu, Irfan
Sargin, Gokhan
Kadikoylu, Gurhan
Doğer, Firuzan Kaçar
author_facet Bolaman, Zahit
Yavasoglu, Irfan
Sargin, Gokhan
Kadikoylu, Gurhan
Doğer, Firuzan Kaçar
author_sort Bolaman, Zahit
collection PubMed
description A 28-year-old man from East Mediterranean area admitted with abdominal pain, weight loss and diarrhea. Barium x-ray studies showed segmentation, dilatation of bowel loops, mucosal folds thickening and delayed intestinal transit. Histological examination of biopsy specimens revealed villous atrophy and plasmacytic infiltration limited to mucosa and submucosa. Computed tomography showed multiple lymphadenopathy in the abdomen. Serum protein electropheresis and immunoelectropheresis indicated elevated IgA concentration. Bone marrow aspiration and biopsy revealed presence of lymphoplasmacytic infiltration. Immunohistochemical analysis of the intestine, lymph nodes showed positivity for CD45, CD-79, CD-20. After tetracycline treatment the patient’s symptoms, abdominal lymphadenopathy and bone marrow infiltration disappeared and IgA concentration decreased to normal levels.
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spelling pubmed-33756732012-06-15 Bone Marrow Involvement in a Patient with Alpha Heavychain Disease: Response to Tetracycline Treatment Bolaman, Zahit Yavasoglu, Irfan Sargin, Gokhan Kadikoylu, Gurhan Doğer, Firuzan Kaçar Mediterr J Hematol Infect Dis Case Report A 28-year-old man from East Mediterranean area admitted with abdominal pain, weight loss and diarrhea. Barium x-ray studies showed segmentation, dilatation of bowel loops, mucosal folds thickening and delayed intestinal transit. Histological examination of biopsy specimens revealed villous atrophy and plasmacytic infiltration limited to mucosa and submucosa. Computed tomography showed multiple lymphadenopathy in the abdomen. Serum protein electropheresis and immunoelectropheresis indicated elevated IgA concentration. Bone marrow aspiration and biopsy revealed presence of lymphoplasmacytic infiltration. Immunohistochemical analysis of the intestine, lymph nodes showed positivity for CD45, CD-79, CD-20. After tetracycline treatment the patient’s symptoms, abdominal lymphadenopathy and bone marrow infiltration disappeared and IgA concentration decreased to normal levels. Università Cattolica del Sacro Cuore 2012-05-07 /pmc/articles/PMC3375673/ /pubmed/22708049 http://dx.doi.org/10.4084/MJHID.2012.034 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Bolaman, Zahit
Yavasoglu, Irfan
Sargin, Gokhan
Kadikoylu, Gurhan
Doğer, Firuzan Kaçar
Bone Marrow Involvement in a Patient with Alpha Heavychain Disease: Response to Tetracycline Treatment
title Bone Marrow Involvement in a Patient with Alpha Heavychain Disease: Response to Tetracycline Treatment
title_full Bone Marrow Involvement in a Patient with Alpha Heavychain Disease: Response to Tetracycline Treatment
title_fullStr Bone Marrow Involvement in a Patient with Alpha Heavychain Disease: Response to Tetracycline Treatment
title_full_unstemmed Bone Marrow Involvement in a Patient with Alpha Heavychain Disease: Response to Tetracycline Treatment
title_short Bone Marrow Involvement in a Patient with Alpha Heavychain Disease: Response to Tetracycline Treatment
title_sort bone marrow involvement in a patient with alpha heavychain disease: response to tetracycline treatment
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375673/
https://www.ncbi.nlm.nih.gov/pubmed/22708049
http://dx.doi.org/10.4084/MJHID.2012.034
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