The CD95 signaling pathway: To not die and fly

Our recent findings indicate that cells exposed to transmembrane (m-CD95L) or metalloprotease-cleaved CD95L (cl-CD95L) undergo a localized Ca(2+)entry that not only inhibits the initial steps of the CD95-mediated apoptotic signal but also promotes cell motility. Based on recent findings published on...

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Detalles Bibliográficos
Autores principales: Penna, Aubin, Khadra, Nadine, Tauzin, Sébastien, Vacher, Pierre, Legembre, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Article Addendum
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376061/
https://www.ncbi.nlm.nih.gov/pubmed/22808330
http://dx.doi.org/10.4161/cib.18888
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author Penna, Aubin
Khadra, Nadine
Tauzin, Sébastien
Vacher, Pierre
Legembre, Patrick
author_facet Penna, Aubin
Khadra, Nadine
Tauzin, Sébastien
Vacher, Pierre
Legembre, Patrick
author_sort Penna, Aubin
collection PubMed
description Our recent findings indicate that cells exposed to transmembrane (m-CD95L) or metalloprotease-cleaved CD95L (cl-CD95L) undergo a localized Ca(2+)entry that not only inhibits the initial steps of the CD95-mediated apoptotic signal but also promotes cell motility. Based on recent findings published on the non-apoptotic signals induced by CD95, we discuss how m-CD95L and cl-CD95L diverging by their stoichiometry could both contribute to the immune response by first recruiting activated T lymphocytes in the inflamed area and later by eliminating infected and transformed cells.
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spelling pubmed-33760612012-07-17 The CD95 signaling pathway: To not die and fly Penna, Aubin Khadra, Nadine Tauzin, Sébastien Vacher, Pierre Legembre, Patrick Commun Integr Biol Article Addendum Our recent findings indicate that cells exposed to transmembrane (m-CD95L) or metalloprotease-cleaved CD95L (cl-CD95L) undergo a localized Ca(2+)entry that not only inhibits the initial steps of the CD95-mediated apoptotic signal but also promotes cell motility. Based on recent findings published on the non-apoptotic signals induced by CD95, we discuss how m-CD95L and cl-CD95L diverging by their stoichiometry could both contribute to the immune response by first recruiting activated T lymphocytes in the inflamed area and later by eliminating infected and transformed cells. Landes Bioscience 2012-03-01 /pmc/articles/PMC3376061/ /pubmed/22808330 http://dx.doi.org/10.4161/cib.18888 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Article Addendum
Penna, Aubin
Khadra, Nadine
Tauzin, Sébastien
Vacher, Pierre
Legembre, Patrick
The CD95 signaling pathway: To not die and fly
title The CD95 signaling pathway: To not die and fly
title_full The CD95 signaling pathway: To not die and fly
title_fullStr The CD95 signaling pathway: To not die and fly
title_full_unstemmed The CD95 signaling pathway: To not die and fly
title_short The CD95 signaling pathway: To not die and fly
title_sort cd95 signaling pathway: to not die and fly
topic Article Addendum
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376061/
https://www.ncbi.nlm.nih.gov/pubmed/22808330
http://dx.doi.org/10.4161/cib.18888
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