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Dynamics of mitochondrial raft-like microdomains in cell life and death
On the basis of the biochemical nature of lipid rafts, composed by glycosphingolipids, cholesterol and signaling proteins, it has been suggested that they are part of the complex framework of subcellular intermixing activities that lead to CD95/Fas-triggered apoptosis. We demonstrated that, followin...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Landes Bioscience
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376069/ https://www.ncbi.nlm.nih.gov/pubmed/22808338 http://dx.doi.org/10.4161/cib.19145 |
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author | Sorice, Maurizio Mattei, Vincenzo Matarrese, Paola Garofalo, Tina Tinari, Antonella Gambardella, Lucrezia Ciarlo, Laura Manganelli, Valeria Tasciotti, Vincenzo Misasi, Roberta Malorni, Walter |
author_facet | Sorice, Maurizio Mattei, Vincenzo Matarrese, Paola Garofalo, Tina Tinari, Antonella Gambardella, Lucrezia Ciarlo, Laura Manganelli, Valeria Tasciotti, Vincenzo Misasi, Roberta Malorni, Walter |
author_sort | Sorice, Maurizio |
collection | PubMed |
description | On the basis of the biochemical nature of lipid rafts, composed by glycosphingolipids, cholesterol and signaling proteins, it has been suggested that they are part of the complex framework of subcellular intermixing activities that lead to CD95/Fas-triggered apoptosis. We demonstrated that, following CD95/Fas triggering, cellular prion protein (PrP(C)), which represents a paradigmatic component of lipid rafts, was redistributed to mitochondrial raft-like microdomains via endoplasmic reticulum (ER)-mitochondria associated membranes (MAM) and microtubular network. Raft-like microdomains appear to be involved in a series of intracellular functions, such as: (1) the membrane “scrambling” that participates in cell death execution pathways, (2) the remodeling of organelles, (3) the recruitment of proteins to the mitochondria; (4) the mitochondrial oxidative phosphorylation and ATP production. In conclusion, we suggest that lipid raft components can exert their regulatory activity in apoptosis execution at three different levels: (1) in the DISC formation at the plasma membrane; (2) in the intracellular redistribution at cytoplasmic organelles, and, (3) in the structural and functional mitochondrial modifications associated with apoptosis execution. |
format | Online Article Text |
id | pubmed-3376069 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Landes Bioscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-33760692012-07-17 Dynamics of mitochondrial raft-like microdomains in cell life and death Sorice, Maurizio Mattei, Vincenzo Matarrese, Paola Garofalo, Tina Tinari, Antonella Gambardella, Lucrezia Ciarlo, Laura Manganelli, Valeria Tasciotti, Vincenzo Misasi, Roberta Malorni, Walter Commun Integr Biol Article Addendum On the basis of the biochemical nature of lipid rafts, composed by glycosphingolipids, cholesterol and signaling proteins, it has been suggested that they are part of the complex framework of subcellular intermixing activities that lead to CD95/Fas-triggered apoptosis. We demonstrated that, following CD95/Fas triggering, cellular prion protein (PrP(C)), which represents a paradigmatic component of lipid rafts, was redistributed to mitochondrial raft-like microdomains via endoplasmic reticulum (ER)-mitochondria associated membranes (MAM) and microtubular network. Raft-like microdomains appear to be involved in a series of intracellular functions, such as: (1) the membrane “scrambling” that participates in cell death execution pathways, (2) the remodeling of organelles, (3) the recruitment of proteins to the mitochondria; (4) the mitochondrial oxidative phosphorylation and ATP production. In conclusion, we suggest that lipid raft components can exert their regulatory activity in apoptosis execution at three different levels: (1) in the DISC formation at the plasma membrane; (2) in the intracellular redistribution at cytoplasmic organelles, and, (3) in the structural and functional mitochondrial modifications associated with apoptosis execution. Landes Bioscience 2012-03-01 /pmc/articles/PMC3376069/ /pubmed/22808338 http://dx.doi.org/10.4161/cib.19145 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Article Addendum Sorice, Maurizio Mattei, Vincenzo Matarrese, Paola Garofalo, Tina Tinari, Antonella Gambardella, Lucrezia Ciarlo, Laura Manganelli, Valeria Tasciotti, Vincenzo Misasi, Roberta Malorni, Walter Dynamics of mitochondrial raft-like microdomains in cell life and death |
title | Dynamics of mitochondrial raft-like microdomains in cell life and death |
title_full | Dynamics of mitochondrial raft-like microdomains in cell life and death |
title_fullStr | Dynamics of mitochondrial raft-like microdomains in cell life and death |
title_full_unstemmed | Dynamics of mitochondrial raft-like microdomains in cell life and death |
title_short | Dynamics of mitochondrial raft-like microdomains in cell life and death |
title_sort | dynamics of mitochondrial raft-like microdomains in cell life and death |
topic | Article Addendum |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376069/ https://www.ncbi.nlm.nih.gov/pubmed/22808338 http://dx.doi.org/10.4161/cib.19145 |
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