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Dynamics of mitochondrial raft-like microdomains in cell life and death

On the basis of the biochemical nature of lipid rafts, composed by glycosphingolipids, cholesterol and signaling proteins, it has been suggested that they are part of the complex framework of subcellular intermixing activities that lead to CD95/Fas-triggered apoptosis. We demonstrated that, followin...

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Autores principales: Sorice, Maurizio, Mattei, Vincenzo, Matarrese, Paola, Garofalo, Tina, Tinari, Antonella, Gambardella, Lucrezia, Ciarlo, Laura, Manganelli, Valeria, Tasciotti, Vincenzo, Misasi, Roberta, Malorni, Walter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376069/
https://www.ncbi.nlm.nih.gov/pubmed/22808338
http://dx.doi.org/10.4161/cib.19145
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author Sorice, Maurizio
Mattei, Vincenzo
Matarrese, Paola
Garofalo, Tina
Tinari, Antonella
Gambardella, Lucrezia
Ciarlo, Laura
Manganelli, Valeria
Tasciotti, Vincenzo
Misasi, Roberta
Malorni, Walter
author_facet Sorice, Maurizio
Mattei, Vincenzo
Matarrese, Paola
Garofalo, Tina
Tinari, Antonella
Gambardella, Lucrezia
Ciarlo, Laura
Manganelli, Valeria
Tasciotti, Vincenzo
Misasi, Roberta
Malorni, Walter
author_sort Sorice, Maurizio
collection PubMed
description On the basis of the biochemical nature of lipid rafts, composed by glycosphingolipids, cholesterol and signaling proteins, it has been suggested that they are part of the complex framework of subcellular intermixing activities that lead to CD95/Fas-triggered apoptosis. We demonstrated that, following CD95/Fas triggering, cellular prion protein (PrP(C)), which represents a paradigmatic component of lipid rafts, was redistributed to mitochondrial raft-like microdomains via endoplasmic reticulum (ER)-mitochondria associated membranes (MAM) and microtubular network.   Raft-like microdomains appear to be involved in a series of intracellular functions, such as: (1) the membrane “scrambling” that participates in cell death execution pathways, (2) the remodeling of organelles, (3) the recruitment of proteins to the mitochondria; (4) the mitochondrial oxidative phosphorylation and ATP production. In conclusion, we suggest that lipid raft components can exert their regulatory activity in apoptosis execution at three different levels: (1) in the DISC formation at the plasma membrane; (2) in the intracellular redistribution at cytoplasmic organelles, and, (3) in the structural and functional mitochondrial modifications associated with apoptosis execution.
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spelling pubmed-33760692012-07-17 Dynamics of mitochondrial raft-like microdomains in cell life and death Sorice, Maurizio Mattei, Vincenzo Matarrese, Paola Garofalo, Tina Tinari, Antonella Gambardella, Lucrezia Ciarlo, Laura Manganelli, Valeria Tasciotti, Vincenzo Misasi, Roberta Malorni, Walter Commun Integr Biol Article Addendum On the basis of the biochemical nature of lipid rafts, composed by glycosphingolipids, cholesterol and signaling proteins, it has been suggested that they are part of the complex framework of subcellular intermixing activities that lead to CD95/Fas-triggered apoptosis. We demonstrated that, following CD95/Fas triggering, cellular prion protein (PrP(C)), which represents a paradigmatic component of lipid rafts, was redistributed to mitochondrial raft-like microdomains via endoplasmic reticulum (ER)-mitochondria associated membranes (MAM) and microtubular network.   Raft-like microdomains appear to be involved in a series of intracellular functions, such as: (1) the membrane “scrambling” that participates in cell death execution pathways, (2) the remodeling of organelles, (3) the recruitment of proteins to the mitochondria; (4) the mitochondrial oxidative phosphorylation and ATP production. In conclusion, we suggest that lipid raft components can exert their regulatory activity in apoptosis execution at three different levels: (1) in the DISC formation at the plasma membrane; (2) in the intracellular redistribution at cytoplasmic organelles, and, (3) in the structural and functional mitochondrial modifications associated with apoptosis execution. Landes Bioscience 2012-03-01 /pmc/articles/PMC3376069/ /pubmed/22808338 http://dx.doi.org/10.4161/cib.19145 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Article Addendum
Sorice, Maurizio
Mattei, Vincenzo
Matarrese, Paola
Garofalo, Tina
Tinari, Antonella
Gambardella, Lucrezia
Ciarlo, Laura
Manganelli, Valeria
Tasciotti, Vincenzo
Misasi, Roberta
Malorni, Walter
Dynamics of mitochondrial raft-like microdomains in cell life and death
title Dynamics of mitochondrial raft-like microdomains in cell life and death
title_full Dynamics of mitochondrial raft-like microdomains in cell life and death
title_fullStr Dynamics of mitochondrial raft-like microdomains in cell life and death
title_full_unstemmed Dynamics of mitochondrial raft-like microdomains in cell life and death
title_short Dynamics of mitochondrial raft-like microdomains in cell life and death
title_sort dynamics of mitochondrial raft-like microdomains in cell life and death
topic Article Addendum
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376069/
https://www.ncbi.nlm.nih.gov/pubmed/22808338
http://dx.doi.org/10.4161/cib.19145
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