Development of Novel Single-Stranded Nucleic Acid Aptamers against the Pro-Angiogenic and Metastatic Enzyme Heparanase (HPSE1)

Heparanase is an enzyme involved in extracellular matrix remodelling and heparan sulphate proteoglycan catabolism. It is secreted by metastatic tumour cells, allowing them to penetrate the endothelial cell layer and basement membrane to invade target organs. The release of growth factors at the site...

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Detalles Bibliográficos
Autores principales: Simmons, Suzanne C., McKenzie, Edward A., Harris, Lynda K., Aplin, John D., Brenchley, Paul E., Velasco-Garcia, Maria N., Missailidis, Sotiris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376095/
https://www.ncbi.nlm.nih.gov/pubmed/22719856
http://dx.doi.org/10.1371/journal.pone.0037938

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