A Two-Step Target Binding and Selectivity Support Vector Machines Approach for Virtual Screening of Dopamine Receptor Subtype-Selective Ligands

Target selective drugs, such as dopamine receptor (DR) subtype selective ligands, are developed for enhanced therapeutics and reduced side effects. In silico methods have been explored for searching DR selective ligands, but encountered difficulties associated with high subtype similarity and ligand...

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Detalles Bibliográficos
Autores principales: Zhang, Jingxian, Han, Bucong, Wei, Xiaona, Tan, Chunyan, Chen, Yuzong, Jiang, Yuyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376116/
https://www.ncbi.nlm.nih.gov/pubmed/22720033
http://dx.doi.org/10.1371/journal.pone.0039076

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