An Artificial miRNA against HPSE Suppresses Melanoma Invasion Properties, Correlating with a Down-Regulation of Chemokines and MAPK Phosphorylation

Ribonucleic acid interference (RNAi) based on microRNA (miRNA) context may provide an efficient and safe therapeutic knockdown effect and can be driven by ribonucleic acid polymerase II (RNAP II). In this study, we designed and synthesized miR155-based artificial miRNAs against heparanase (HPSE) con...

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Detalles Bibliográficos
Autores principales: Liu, Xiaoyan, Fang, Hong, Chen, Hongchao, Jiang, Xiaoling, Fang, Deren, Wang, Yan, Zhu, Dingxian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376136/
https://www.ncbi.nlm.nih.gov/pubmed/22719918
http://dx.doi.org/10.1371/journal.pone.0038659

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