Cargando…

Real-Time Monitoring of Tumorigenesis, Dissemination, & Drug Response in a Preclinical Model of Lymphangioleiomyomatosis/Tuberous Sclerosis Complex

BACKGROUND: TSC2-deficient cells can proliferate in the lungs, kidneys, and other organs causing devastating progressive multisystem disorders such as lymphangioleiomyomatosis (LAM) and tuberous sclerosis complex (TSC). Preclinical models utilizing LAM patient-derived cells have been difficult to es...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Fangbing, Lunsford, Elaine P., Tong, Jingli, Ashitate, Yoshitomo, Gibbs, Summer L., Yu, Jane, Choi, Hak Soo, Henske, Elizabeth P., Frangioni, John V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376142/ https://www.ncbi.nlm.nih.gov/pubmed/22719903 http://dx.doi.org/10.1371/journal.pone.0038589

Ejemplares similares

MicroRNA-21 is Induced by Rapamycin in a Model of Tuberous Sclerosis (TSC) and Lymphangioleiomyomatosis (LAM)
por: Trindade, Anil J., et al.
Publicado: (2013)

Lymphangioleiomyomatosis Associated with Tuberous Sclerosis Complex
por: Tanitame, Keizo
Publicado: (2020)

Tuberous sclerosis complex associated lymphangioleiomyomatosis
por: Han, Z, et al.
Publicado: (2023)

Serum endostatin levels are associated with diffusion capacity and with tuberous sclerosis- associated lymphangioleiomyomatosis
por: Lamattina, Anthony M., et al.
Publicado: (2019)

Pneumothorax as a Presentation of Tuberous Sclerosis-Associated Lymphangioleiomyomatosis
por: Silva, Duarte Lages, et al.
Publicado: (2019)

Lymphangioleiomyomatosis with Tuberous Sclerosis Complex—A Case Study
por: Marciniak, Aleksandra, et al.
Publicado: (2023)

A Case of Uterine Lymphangioleiomyomatosis Complicated by Tuberous Sclerosis Complex
por: Yamada, Kaori, et al.
Publicado: (2022)

A rare pulmonary lymphangioleiomyomatosis disease in a male with tuberous sclerosis complex
por: Kabi, Ankita, et al.
Publicado: (2020)

Tuberous sclerosis complex presenting as pulmonary lymphangioleiomyomatosis - a clinicoradiological diagnosis
por: Gupta, Kamini, et al.
Publicado: (2015)

A Case of Tuberous Sclerosis Complex with Lymphangioleiomyomatosis and Renal Cell Carcinoma
por: Wu, Yun, et al.
Publicado: (2020)

Rapamycin-Insensitive Up-Regulation of Adipocyte Phospholipase A2 in Tuberous Sclerosis and Lymphangioleiomyomatosis
por: Li, Chenggang, et al.
Publicado: (2014)

The neural crest lineage as a driver of disease heterogeneity in Tuberous Sclerosis Complex and Lymphangioleiomyomatosis
por: Delaney, Sean P., et al.
Publicado: (2014)

Tuberous Sclerosis Complex Associated with Papillary Serous Carcinoma of the Peritoneum, Lymphangioleiomyomatosis, and Angiomyolipoma
por: Wakamiya, Tomihiro, et al.
Publicado: (2011)

Leiomyomatosis-like lymphangioleiomyomatosis: A case report of the colonic manifestation of tuberous sclerosis
por: Erginoz, Ergin, et al.
Publicado: (2021)

Hyponatremia: A Tip of the Iceberg in the Late Diagnosis of Tuberous Sclerosis Associated With Lymphangioleiomyomatosis
por: Paiva, David, et al.
Publicado: (2021)

Vps34-mediated macropinocytosis in Tuberous Sclerosis Complex 2-deficient cells supports tumorigenesis
por: Filippakis, Harilaos, et al.
Publicado: (2018)

Tuberous sclerosis complex-lymphangioleiomyomatosis involving several visceral organs: A case report
por: Chen, Hong-Bin, et al.
Publicado: (2021)

Renal Cell Carcinoma in Tuberous Sclerosis Complex
por: Henske, Elizabeth P., et al.
Publicado: (2021)

Towards personalised therapy for lymphangioleiomyomatosis: lessons from cancer
por: El-Chemaly, Souheil, et al.
Publicado: (2014)

Computed tomographic findings of tuberous sclerosis with pulmonary lymphangioleiomyomatosis and renal angiomyolipomas: a case report
por: Vianna, Flavia Gavinho, et al.
Publicado: (2009)

Tuberous sclerosis with pulmonary lymphangioleiomyomatosis and renal angiomyolipomas. Computed tomographic findings: a case report
por: Vianna, Flávia G, et al.
Publicado: (2009)

Simultaneous Mapping of Pan and Sentinel Lymph Nodes for Real-Time Image-Guided Surgery
por: Ashitate, Yoshitomo, et al.
Publicado: (2014)

Reprogramming patient-derived tumor cells generates model cell lines for tuberous sclerosis-associated lymphangioleiomyomatosis
por: Julian, Lisa M., et al.
Publicado: (2017)

Angiomyolipoma rebound tumor growth after discontinuation of everolimus in patients with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis
por: Bissler, John J., et al.
Publicado: (2018)

Exploring the Role of Matrix Metalloproteinases as Biomarkers in Sporadic Lymphangioleiomyomatosis and Tuberous Sclerosis Complex. A Pilot Study
por: Terraneo, Silvia, et al.
Publicado: (2021)

Structure-Activity Relationship of Nerve-Highlighting Fluorophores
por: Gibbs, Summer L., et al.
Publicado: (2013)

Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis
por: Neuman, Nicole A, et al.
Publicado: (2011)

The effect of mTOR inhibitors on respiratory infections in lymphangioleiomyomatosis
por: Courtwright, Andrew M., et al.
Publicado: (2017)

Near-Infrared Fluorescence Imaging for Noninvasive Trafficking of Scaffold Degradation
por: Kim, Soon Hee, et al.
Publicado: (2013)

Lymphangioleiomyomatosis: circulating levels of FGF23 and pulmonary diffusion
por: Esposito, Anthony J, et al.
Publicado: (2023)

Kidney intercalated cells and the transcription factor FOXi1 drive cystogenesis in tuberous sclerosis complex
por: Barone, Sharon, et al.
Publicado: (2021)

Prototype Nerve-Specific Near-Infrared Fluorophores
por: Park, Min Ho, et al.
Publicado: (2014)

mTORC1 hyperactivation in lymphangioleiomyomatosis leads to ACE2 upregulation in type II pneumocytes: implications for COVID-19
por: Tang, Yan, et al.
Publicado: (2021)

Protease activity sensors enable real-time treatment response monitoring in lymphangioleiomyomatosis
por: Kirkpatrick, Jesse D., et al.
Publicado: (2022)

Spectrum of germline and somatic mitochondrial DNA variants in Tuberous Sclerosis Complex
por: Giannikou, Krinio, et al.
Publicado: (2023)

Lung-selective mRNA delivery of synthetic lipid nanoparticles for the treatment of pulmonary lymphangioleiomyomatosis
por: Qiu, Min, et al.
Publicado: (2022)

Tuberous sclerosis
por: George, Anisha, et al.
Publicado: (2015)

The tuberous sclerosis proteins regulate formation of the primary cilium via a rapamycin-insensitive and polycystin 1-independent pathway
por: Hartman, Tiffiney R., et al.
Publicado: (2009)

Lysosomal regulation of cholesterol homeostasis in tuberous sclerosis complex is mediated via NPC1 and LDL-R
por: Filippakis, Harilaos, et al.
Publicado: (2017)

Management of lymphangioleiomyomatosis
por: Taveira-DaSilva, Angelo M., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_gv62mn1gh24eertie0b4hnaq8g