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Impaired sodium excretion and salt-sensitive hypertension in corin-deficient mice

Corin is a protease that activates atrial natriuretic peptide, a cardiac hormone important in the control of blood pressure and salt-water balance. Here we examined the role of corin in regulating blood pressure and sodium homeostasis upon dietary salt challenge. Radiotelemetry-tracked blood pressur...

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Autores principales: Wang, Wei, Shen, Jianzhong, Cui, Yujie, Jiang, Jingjing, Chen, Shenghan, Peng, Jianhao, Wu, Qingyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376235/
https://www.ncbi.nlm.nih.gov/pubmed/22418978
http://dx.doi.org/10.1038/ki.2012.41
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author Wang, Wei
Shen, Jianzhong
Cui, Yujie
Jiang, Jingjing
Chen, Shenghan
Peng, Jianhao
Wu, Qingyu
author_facet Wang, Wei
Shen, Jianzhong
Cui, Yujie
Jiang, Jingjing
Chen, Shenghan
Peng, Jianhao
Wu, Qingyu
author_sort Wang, Wei
collection PubMed
description Corin is a protease that activates atrial natriuretic peptide, a cardiac hormone important in the control of blood pressure and salt-water balance. Here we examined the role of corin in regulating blood pressure and sodium homeostasis upon dietary salt challenge. Radiotelemetry-tracked blood pressure in corin knockout mice on a high salt diet (4% sodium chloride) was significantly increased; however, there was no such change in similarly treated wild type mice. In the knockout mice on the high salt diet there was an impairment of urinary sodium excretion and an increase in body weight, but no elevation of plasma renin or serum aldosterone levels. When the knockout mice on the high salt diet were treated with amiloride, an epithelial sodium channel blocker that inhibits renal sodium reabsorption, the impaired urinary sodium excretion and increased body weight were normalized. Amiloride treatment also reduced high blood pressure caused by the high salt diet in these mice. Thus, the lack of corin in mice impairs their adaptive renal response to high dietary salt, suggesting that corin deficiency may represent an important mechanism underlying salt-sensitive hypertension.
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spelling pubmed-33762352013-01-01 Impaired sodium excretion and salt-sensitive hypertension in corin-deficient mice Wang, Wei Shen, Jianzhong Cui, Yujie Jiang, Jingjing Chen, Shenghan Peng, Jianhao Wu, Qingyu Kidney Int Article Corin is a protease that activates atrial natriuretic peptide, a cardiac hormone important in the control of blood pressure and salt-water balance. Here we examined the role of corin in regulating blood pressure and sodium homeostasis upon dietary salt challenge. Radiotelemetry-tracked blood pressure in corin knockout mice on a high salt diet (4% sodium chloride) was significantly increased; however, there was no such change in similarly treated wild type mice. In the knockout mice on the high salt diet there was an impairment of urinary sodium excretion and an increase in body weight, but no elevation of plasma renin or serum aldosterone levels. When the knockout mice on the high salt diet were treated with amiloride, an epithelial sodium channel blocker that inhibits renal sodium reabsorption, the impaired urinary sodium excretion and increased body weight were normalized. Amiloride treatment also reduced high blood pressure caused by the high salt diet in these mice. Thus, the lack of corin in mice impairs their adaptive renal response to high dietary salt, suggesting that corin deficiency may represent an important mechanism underlying salt-sensitive hypertension. 2012-03-14 2012-07 /pmc/articles/PMC3376235/ /pubmed/22418978 http://dx.doi.org/10.1038/ki.2012.41 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Wang, Wei
Shen, Jianzhong
Cui, Yujie
Jiang, Jingjing
Chen, Shenghan
Peng, Jianhao
Wu, Qingyu
Impaired sodium excretion and salt-sensitive hypertension in corin-deficient mice
title Impaired sodium excretion and salt-sensitive hypertension in corin-deficient mice
title_full Impaired sodium excretion and salt-sensitive hypertension in corin-deficient mice
title_fullStr Impaired sodium excretion and salt-sensitive hypertension in corin-deficient mice
title_full_unstemmed Impaired sodium excretion and salt-sensitive hypertension in corin-deficient mice
title_short Impaired sodium excretion and salt-sensitive hypertension in corin-deficient mice
title_sort impaired sodium excretion and salt-sensitive hypertension in corin-deficient mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376235/
https://www.ncbi.nlm.nih.gov/pubmed/22418978
http://dx.doi.org/10.1038/ki.2012.41
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