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SIRT1 deacetylase promotes acquisition of genetic mutations for drug resistance in CML cells

BCR-ABL transforms bone marrow progenitor cells and promotes genome instability, leading to development of chronic myelogenous leukemia (CML). The tyrosine kinase inhibitor imatinib effectively treats CML, but acquired resistance can develop due to BCR-ABL mutations. Mechanisms for acquisition of BC...

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Detalles Bibliográficos
Autores principales:	Wang, Zhiqiang, Yuan, Hongfeng, Roth, Mendel, Stark, Jeremy M., Bhatia, Ravi, Chen, WenYong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376246/ https://www.ncbi.nlm.nih.gov/pubmed/22410779 http://dx.doi.org/10.1038/onc.2012.83

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