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A Case of Autoimmune Hepatitis and Bisphosphonate-Related Osteonecrosis of the Jaw
Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease of unknown aetiology usually requiring long-term immunosuppressive therapy. We present the case of an AIH patient who received long-term corticosteroids and azathioprine. As treatment for concomitant osteoporosis she was also treated...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376336/ https://www.ncbi.nlm.nih.gov/pubmed/22754491 http://dx.doi.org/10.1159/000339215 |
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author | de Boer, Y.S. Bouma, G. Wattjes, M.P. Lips, P. Mulder, C.J.J. van Nieuwkerk, C.M.J. |
author_facet | de Boer, Y.S. Bouma, G. Wattjes, M.P. Lips, P. Mulder, C.J.J. van Nieuwkerk, C.M.J. |
author_sort | de Boer, Y.S. |
collection | PubMed |
description | Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease of unknown aetiology usually requiring long-term immunosuppressive therapy. We present the case of an AIH patient who received long-term corticosteroids and azathioprine. As treatment for concomitant osteoporosis she was also treated with potent intravenous bisphosphonate (BP). This treatment was complicated by the development of BP-related osteonecrosis of the jaw (BRONJ). BRONJ is an uncommon complication of BP treatment regimes that occurs at increased frequency in the presence of other risk factors, including chronic inflammatory conditions. Our patient suffered from a severe and complicated clinical course of BRONJ which, despite adequate therapy, resulted in death of the patient. Here we discuss the risk factors for the development and clinical course of BRONJ in AIH and the implications for management of these patients. |
format | Online Article Text |
id | pubmed-3376336 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-33763362012-07-02 A Case of Autoimmune Hepatitis and Bisphosphonate-Related Osteonecrosis of the Jaw de Boer, Y.S. Bouma, G. Wattjes, M.P. Lips, P. Mulder, C.J.J. van Nieuwkerk, C.M.J. Case Rep Gastroenterol Published: May, 2012 Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease of unknown aetiology usually requiring long-term immunosuppressive therapy. We present the case of an AIH patient who received long-term corticosteroids and azathioprine. As treatment for concomitant osteoporosis she was also treated with potent intravenous bisphosphonate (BP). This treatment was complicated by the development of BP-related osteonecrosis of the jaw (BRONJ). BRONJ is an uncommon complication of BP treatment regimes that occurs at increased frequency in the presence of other risk factors, including chronic inflammatory conditions. Our patient suffered from a severe and complicated clinical course of BRONJ which, despite adequate therapy, resulted in death of the patient. Here we discuss the risk factors for the development and clinical course of BRONJ in AIH and the implications for management of these patients. S. Karger AG 2012-05-23 /pmc/articles/PMC3376336/ /pubmed/22754491 http://dx.doi.org/10.1159/000339215 Text en Copyright © 2012 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions. |
spellingShingle | Published: May, 2012 de Boer, Y.S. Bouma, G. Wattjes, M.P. Lips, P. Mulder, C.J.J. van Nieuwkerk, C.M.J. A Case of Autoimmune Hepatitis and Bisphosphonate-Related Osteonecrosis of the Jaw |
title | A Case of Autoimmune Hepatitis and Bisphosphonate-Related Osteonecrosis of the Jaw |
title_full | A Case of Autoimmune Hepatitis and Bisphosphonate-Related Osteonecrosis of the Jaw |
title_fullStr | A Case of Autoimmune Hepatitis and Bisphosphonate-Related Osteonecrosis of the Jaw |
title_full_unstemmed | A Case of Autoimmune Hepatitis and Bisphosphonate-Related Osteonecrosis of the Jaw |
title_short | A Case of Autoimmune Hepatitis and Bisphosphonate-Related Osteonecrosis of the Jaw |
title_sort | case of autoimmune hepatitis and bisphosphonate-related osteonecrosis of the jaw |
topic | Published: May, 2012 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376336/ https://www.ncbi.nlm.nih.gov/pubmed/22754491 http://dx.doi.org/10.1159/000339215 |
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