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Reducing Bias of Allele Frequency Estimates by Modeling SNP Genotype Data with Informative Missingness
The presence of missing single-nucleotide polymorphism (SNP) genotypes is common in genetic studies. For studies with low-density SNPs, the most commonly used approach to dealing with genotype missingness is to simply remove the observations with missing genotypes from the analyses. This naïve metho...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Research Foundation
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376470/ https://www.ncbi.nlm.nih.gov/pubmed/22719749 http://dx.doi.org/10.3389/fgene.2012.00107 |