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Photosensitive-polyimide based method for fabricating various neural electrode architectures

An extensive photosensitive-polyimide (PSPI)-based method for designing and fabricating various neural electrode architectures was developed. The method aims to broaden the design flexibility and expand the fabrication capability for neural electrodes to improve the quality of recorded signals and i...

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Autores principales: Kato, Yasuhiro X., Furukawa, Shigeto, Samejima, Kazuyuki, Hironaka, Naoyuki, Kashino, Makio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376501/
https://www.ncbi.nlm.nih.gov/pubmed/22719725
http://dx.doi.org/10.3389/fneng.2012.00011
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author Kato, Yasuhiro X.
Furukawa, Shigeto
Samejima, Kazuyuki
Hironaka, Naoyuki
Kashino, Makio
author_facet Kato, Yasuhiro X.
Furukawa, Shigeto
Samejima, Kazuyuki
Hironaka, Naoyuki
Kashino, Makio
author_sort Kato, Yasuhiro X.
collection PubMed
description An extensive photosensitive-polyimide (PSPI)-based method for designing and fabricating various neural electrode architectures was developed. The method aims to broaden the design flexibility and expand the fabrication capability for neural electrodes to improve the quality of recorded signals and integrate other functions. After characterizing PSPI's properties for micromachining processes, we successfully designed and fabricated various neural electrodes even on a non-flat substrate using only one PSPI as an insulation material and without the time-consuming dry etching processes. The fabricated neural electrodes were an electrocorticogram (ECoG) electrode, a mesh intracortical electrode with a unique lattice-like mesh structure to fixate neural tissue, and a guide cannula electrode with recording microelectrodes placed on the curved surface of a guide cannula as a microdialysis probe. In vivo neural recordings using anesthetized rats demonstrated that these electrodes can be used to record neural activities repeatedly without any breakage and mechanical failures, which potentially promises stable recordings for long periods of time. These successes make us believe that this PSPI-based fabrication is a powerful method, permitting flexible design, and easy optimization of electrode architectures for a variety of electrophysiological experimental research with improved neural recording performance.
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spelling pubmed-33765012012-06-20 Photosensitive-polyimide based method for fabricating various neural electrode architectures Kato, Yasuhiro X. Furukawa, Shigeto Samejima, Kazuyuki Hironaka, Naoyuki Kashino, Makio Front Neuroeng Neuroscience An extensive photosensitive-polyimide (PSPI)-based method for designing and fabricating various neural electrode architectures was developed. The method aims to broaden the design flexibility and expand the fabrication capability for neural electrodes to improve the quality of recorded signals and integrate other functions. After characterizing PSPI's properties for micromachining processes, we successfully designed and fabricated various neural electrodes even on a non-flat substrate using only one PSPI as an insulation material and without the time-consuming dry etching processes. The fabricated neural electrodes were an electrocorticogram (ECoG) electrode, a mesh intracortical electrode with a unique lattice-like mesh structure to fixate neural tissue, and a guide cannula electrode with recording microelectrodes placed on the curved surface of a guide cannula as a microdialysis probe. In vivo neural recordings using anesthetized rats demonstrated that these electrodes can be used to record neural activities repeatedly without any breakage and mechanical failures, which potentially promises stable recordings for long periods of time. These successes make us believe that this PSPI-based fabrication is a powerful method, permitting flexible design, and easy optimization of electrode architectures for a variety of electrophysiological experimental research with improved neural recording performance. Frontiers Media S.A. 2012-06-18 /pmc/articles/PMC3376501/ /pubmed/22719725 http://dx.doi.org/10.3389/fneng.2012.00011 Text en Copyright © 2012 Kato, Furukawa, Samejima, Hironaka and Kashino. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.
spellingShingle Neuroscience
Kato, Yasuhiro X.
Furukawa, Shigeto
Samejima, Kazuyuki
Hironaka, Naoyuki
Kashino, Makio
Photosensitive-polyimide based method for fabricating various neural electrode architectures
title Photosensitive-polyimide based method for fabricating various neural electrode architectures
title_full Photosensitive-polyimide based method for fabricating various neural electrode architectures
title_fullStr Photosensitive-polyimide based method for fabricating various neural electrode architectures
title_full_unstemmed Photosensitive-polyimide based method for fabricating various neural electrode architectures
title_short Photosensitive-polyimide based method for fabricating various neural electrode architectures
title_sort photosensitive-polyimide based method for fabricating various neural electrode architectures
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376501/
https://www.ncbi.nlm.nih.gov/pubmed/22719725
http://dx.doi.org/10.3389/fneng.2012.00011
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