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The Use of Functional MRI to Study Appetite Control in the CNS

Functional magnetic resonance imaging (fMRI) has provided the opportunity to safely investigate the workings of the human brain. This paper focuses on its use in the field of human appetitive behaviour and its impact in obesity research. In the present absence of any safe or effective centrally acti...

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Detalles Bibliográficos
Autores principales: De Silva, Akila, Salem, Victoria, Matthews, Paul M., Dhillo, Waljit S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376546/
https://www.ncbi.nlm.nih.gov/pubmed/22719753
http://dx.doi.org/10.1155/2012/764017
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author De Silva, Akila
Salem, Victoria
Matthews, Paul M.
Dhillo, Waljit S.
author_facet De Silva, Akila
Salem, Victoria
Matthews, Paul M.
Dhillo, Waljit S.
author_sort De Silva, Akila
collection PubMed
description Functional magnetic resonance imaging (fMRI) has provided the opportunity to safely investigate the workings of the human brain. This paper focuses on its use in the field of human appetitive behaviour and its impact in obesity research. In the present absence of any safe or effective centrally acting appetite suppressants, a better understanding of how appetite is controlled is vital for the development of new antiobesity pharmacotherapies. Early functional imaging techniques revealed an attenuation of brain reward area activity in response to visual food stimuli when humans are fed—in other words, the physiological state of hunger somehow increases the appeal value of food. Later studies have investigated the action of appetite modulating hormones on the fMRI signal, showing how the attenuation of brain reward region activity that follows feeding can be recreated in the fasted state by the administration of anorectic gut hormones. Furthermore, differences in brain activity between obese and lean individuals have provided clues about the possible aetiology of overeating. The hypothalamus acts as a central gateway modulating homeostatic and nonhomeostatic drives to eat. As fMRI techniques constantly improve, functional data regarding the role of this small but hugely important structure in appetite control is emerging.
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spelling pubmed-33765462012-06-20 The Use of Functional MRI to Study Appetite Control in the CNS De Silva, Akila Salem, Victoria Matthews, Paul M. Dhillo, Waljit S. Exp Diabetes Res Review Article Functional magnetic resonance imaging (fMRI) has provided the opportunity to safely investigate the workings of the human brain. This paper focuses on its use in the field of human appetitive behaviour and its impact in obesity research. In the present absence of any safe or effective centrally acting appetite suppressants, a better understanding of how appetite is controlled is vital for the development of new antiobesity pharmacotherapies. Early functional imaging techniques revealed an attenuation of brain reward area activity in response to visual food stimuli when humans are fed—in other words, the physiological state of hunger somehow increases the appeal value of food. Later studies have investigated the action of appetite modulating hormones on the fMRI signal, showing how the attenuation of brain reward region activity that follows feeding can be recreated in the fasted state by the administration of anorectic gut hormones. Furthermore, differences in brain activity between obese and lean individuals have provided clues about the possible aetiology of overeating. The hypothalamus acts as a central gateway modulating homeostatic and nonhomeostatic drives to eat. As fMRI techniques constantly improve, functional data regarding the role of this small but hugely important structure in appetite control is emerging. Hindawi Publishing Corporation 2012 2012-05-08 /pmc/articles/PMC3376546/ /pubmed/22719753 http://dx.doi.org/10.1155/2012/764017 Text en Copyright © 2012 Akila De Silva et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
De Silva, Akila
Salem, Victoria
Matthews, Paul M.
Dhillo, Waljit S.
The Use of Functional MRI to Study Appetite Control in the CNS
title The Use of Functional MRI to Study Appetite Control in the CNS
title_full The Use of Functional MRI to Study Appetite Control in the CNS
title_fullStr The Use of Functional MRI to Study Appetite Control in the CNS
title_full_unstemmed The Use of Functional MRI to Study Appetite Control in the CNS
title_short The Use of Functional MRI to Study Appetite Control in the CNS
title_sort use of functional mri to study appetite control in the cns
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376546/
https://www.ncbi.nlm.nih.gov/pubmed/22719753
http://dx.doi.org/10.1155/2012/764017
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