Drosophila as a model system to unravel the layers of innate immunity to infection

Innate immunity relies entirely upon germ-line encoded receptors, signalling components and effector molecules for the recognition and elimination of invading pathogens. The fruit fly Drosophila melanogaster with its powerful collection of genetic and genomic tools has been the model of choice to de...

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Detalles Bibliográficos
Autores principales: Kounatidis, Ilias, Ligoxygakis, Petros
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376734/
https://www.ncbi.nlm.nih.gov/pubmed/22724070
http://dx.doi.org/10.1098/rsob.120075
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author Kounatidis, Ilias
Ligoxygakis, Petros
author_facet Kounatidis, Ilias
Ligoxygakis, Petros
author_sort Kounatidis, Ilias
collection PubMed
description Innate immunity relies entirely upon germ-line encoded receptors, signalling components and effector molecules for the recognition and elimination of invading pathogens. The fruit fly Drosophila melanogaster with its powerful collection of genetic and genomic tools has been the model of choice to develop ideas about innate immunity and host–pathogen interactions. Here, we review current research in the field, encompassing all layers of defence from the role of the microbiota to systemic immune activation, and attempt to speculate on future directions and open questions.
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spelling pubmed-33767342012-06-21 Drosophila as a model system to unravel the layers of innate immunity to infection Kounatidis, Ilias Ligoxygakis, Petros Open Biol Review Innate immunity relies entirely upon germ-line encoded receptors, signalling components and effector molecules for the recognition and elimination of invading pathogens. The fruit fly Drosophila melanogaster with its powerful collection of genetic and genomic tools has been the model of choice to develop ideas about innate immunity and host–pathogen interactions. Here, we review current research in the field, encompassing all layers of defence from the role of the microbiota to systemic immune activation, and attempt to speculate on future directions and open questions. The Royal Society 2012-05 /pmc/articles/PMC3376734/ /pubmed/22724070 http://dx.doi.org/10.1098/rsob.120075 Text en http://creativecommons.org/licenses/by/3.0/ © 2012 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, provided the original author and source are credited.
spellingShingle Review
Kounatidis, Ilias
Ligoxygakis, Petros
Drosophila as a model system to unravel the layers of innate immunity to infection
title Drosophila as a model system to unravel the layers of innate immunity to infection
title_full Drosophila as a model system to unravel the layers of innate immunity to infection
title_fullStr Drosophila as a model system to unravel the layers of innate immunity to infection
title_full_unstemmed Drosophila as a model system to unravel the layers of innate immunity to infection
title_short Drosophila as a model system to unravel the layers of innate immunity to infection
title_sort drosophila as a model system to unravel the layers of innate immunity to infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376734/
https://www.ncbi.nlm.nih.gov/pubmed/22724070
http://dx.doi.org/10.1098/rsob.120075
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