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The Th1:Th2 Dichotomy of Pregnancy and Preterm Labour
Pregnancy is a unique immunological state in which a balance of immune tolerance and suppression is needed to protect the fetus without compromising the mother. It has long been established that a bias from the T helper 1 cytokine profile towards the T helper 2 profile contributes towards successful...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376783/ https://www.ncbi.nlm.nih.gov/pubmed/22719180 http://dx.doi.org/10.1155/2012/967629 |
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author | Sykes, Lynne MacIntyre, David A. Yap, Xiao J. Teoh, Tiong Ghee Bennett, Phillip R. |
author_facet | Sykes, Lynne MacIntyre, David A. Yap, Xiao J. Teoh, Tiong Ghee Bennett, Phillip R. |
author_sort | Sykes, Lynne |
collection | PubMed |
description | Pregnancy is a unique immunological state in which a balance of immune tolerance and suppression is needed to protect the fetus without compromising the mother. It has long been established that a bias from the T helper 1 cytokine profile towards the T helper 2 profile contributes towards successful pregnancy maintenance. The majority of publications that report on aberrant Th1:Th2 balance focus on early pregnancy loss and preeclampsia. Over the last few decades, there has been an increased awareness of the role of infection and inflammation in preterm labour, and the search for new biomarkers to predict preterm labour continues. In this paper, we explore the evidence for an aberrant Th1:Th2 profile associated with preterm labour. We also consider the potential for its use in screening women at high risk of preterm labour and for prophylactic therapeutic measures for the prevention of preterm labour and associated neonatal adverse outcomes. |
format | Online Article Text |
id | pubmed-3376783 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33767832012-06-20 The Th1:Th2 Dichotomy of Pregnancy and Preterm Labour Sykes, Lynne MacIntyre, David A. Yap, Xiao J. Teoh, Tiong Ghee Bennett, Phillip R. Mediators Inflamm Review Article Pregnancy is a unique immunological state in which a balance of immune tolerance and suppression is needed to protect the fetus without compromising the mother. It has long been established that a bias from the T helper 1 cytokine profile towards the T helper 2 profile contributes towards successful pregnancy maintenance. The majority of publications that report on aberrant Th1:Th2 balance focus on early pregnancy loss and preeclampsia. Over the last few decades, there has been an increased awareness of the role of infection and inflammation in preterm labour, and the search for new biomarkers to predict preterm labour continues. In this paper, we explore the evidence for an aberrant Th1:Th2 profile associated with preterm labour. We also consider the potential for its use in screening women at high risk of preterm labour and for prophylactic therapeutic measures for the prevention of preterm labour and associated neonatal adverse outcomes. Hindawi Publishing Corporation 2012 2012-06-07 /pmc/articles/PMC3376783/ /pubmed/22719180 http://dx.doi.org/10.1155/2012/967629 Text en Copyright © 2012 Lynne Sykes et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Sykes, Lynne MacIntyre, David A. Yap, Xiao J. Teoh, Tiong Ghee Bennett, Phillip R. The Th1:Th2 Dichotomy of Pregnancy and Preterm Labour |
title | The Th1:Th2 Dichotomy of Pregnancy and Preterm Labour |
title_full | The Th1:Th2 Dichotomy of Pregnancy and Preterm Labour |
title_fullStr | The Th1:Th2 Dichotomy of Pregnancy and Preterm Labour |
title_full_unstemmed | The Th1:Th2 Dichotomy of Pregnancy and Preterm Labour |
title_short | The Th1:Th2 Dichotomy of Pregnancy and Preterm Labour |
title_sort | th1:th2 dichotomy of pregnancy and preterm labour |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376783/ https://www.ncbi.nlm.nih.gov/pubmed/22719180 http://dx.doi.org/10.1155/2012/967629 |
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