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The Th1:Th2 Dichotomy of Pregnancy and Preterm Labour

Pregnancy is a unique immunological state in which a balance of immune tolerance and suppression is needed to protect the fetus without compromising the mother. It has long been established that a bias from the T helper 1 cytokine profile towards the T helper 2 profile contributes towards successful...

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Detalles Bibliográficos
Autores principales: Sykes, Lynne, MacIntyre, David A., Yap, Xiao J., Teoh, Tiong Ghee, Bennett, Phillip R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376783/
https://www.ncbi.nlm.nih.gov/pubmed/22719180
http://dx.doi.org/10.1155/2012/967629
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author Sykes, Lynne
MacIntyre, David A.
Yap, Xiao J.
Teoh, Tiong Ghee
Bennett, Phillip R.
author_facet Sykes, Lynne
MacIntyre, David A.
Yap, Xiao J.
Teoh, Tiong Ghee
Bennett, Phillip R.
author_sort Sykes, Lynne
collection PubMed
description Pregnancy is a unique immunological state in which a balance of immune tolerance and suppression is needed to protect the fetus without compromising the mother. It has long been established that a bias from the T helper 1 cytokine profile towards the T helper 2 profile contributes towards successful pregnancy maintenance. The majority of publications that report on aberrant Th1:Th2 balance focus on early pregnancy loss and preeclampsia. Over the last few decades, there has been an increased awareness of the role of infection and inflammation in preterm labour, and the search for new biomarkers to predict preterm labour continues. In this paper, we explore the evidence for an aberrant Th1:Th2 profile associated with preterm labour. We also consider the potential for its use in screening women at high risk of preterm labour and for prophylactic therapeutic measures for the prevention of preterm labour and associated neonatal adverse outcomes.
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spelling pubmed-33767832012-06-20 The Th1:Th2 Dichotomy of Pregnancy and Preterm Labour Sykes, Lynne MacIntyre, David A. Yap, Xiao J. Teoh, Tiong Ghee Bennett, Phillip R. Mediators Inflamm Review Article Pregnancy is a unique immunological state in which a balance of immune tolerance and suppression is needed to protect the fetus without compromising the mother. It has long been established that a bias from the T helper 1 cytokine profile towards the T helper 2 profile contributes towards successful pregnancy maintenance. The majority of publications that report on aberrant Th1:Th2 balance focus on early pregnancy loss and preeclampsia. Over the last few decades, there has been an increased awareness of the role of infection and inflammation in preterm labour, and the search for new biomarkers to predict preterm labour continues. In this paper, we explore the evidence for an aberrant Th1:Th2 profile associated with preterm labour. We also consider the potential for its use in screening women at high risk of preterm labour and for prophylactic therapeutic measures for the prevention of preterm labour and associated neonatal adverse outcomes. Hindawi Publishing Corporation 2012 2012-06-07 /pmc/articles/PMC3376783/ /pubmed/22719180 http://dx.doi.org/10.1155/2012/967629 Text en Copyright © 2012 Lynne Sykes et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Sykes, Lynne
MacIntyre, David A.
Yap, Xiao J.
Teoh, Tiong Ghee
Bennett, Phillip R.
The Th1:Th2 Dichotomy of Pregnancy and Preterm Labour
title The Th1:Th2 Dichotomy of Pregnancy and Preterm Labour
title_full The Th1:Th2 Dichotomy of Pregnancy and Preterm Labour
title_fullStr The Th1:Th2 Dichotomy of Pregnancy and Preterm Labour
title_full_unstemmed The Th1:Th2 Dichotomy of Pregnancy and Preterm Labour
title_short The Th1:Th2 Dichotomy of Pregnancy and Preterm Labour
title_sort th1:th2 dichotomy of pregnancy and preterm labour
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376783/
https://www.ncbi.nlm.nih.gov/pubmed/22719180
http://dx.doi.org/10.1155/2012/967629
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