Mutant p63 causes defective expansion of ectodermal progenitor cells and impaired FGF signalling in AEC syndrome

Ankyloblepharon-ectodermal defects-cleft lip/palate (AEC) syndrome, which is characterized by cleft palate and severe defects of the skin, is an autosomal dominant disorder caused by mutations in the gene encoding transcription factor p63. Here, we report the generation of a knock-in mouse model for...

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Detalles Bibliográficos
Autores principales: Ferone, Giustina, Thomason, Helen A, Antonini, Dario, De Rosa, Laura, Hu, Bing, Gemei, Marica, Zhou, Huiqing, Ambrosio, Raffaele, Rice, David P, Acampora, Dario, van Bokhoven, Hans, Del Vecchio, Luigi, Koster, Maranke I, Tadini, Gianluca, Spencer-Dene, Bradley, Dixon, Michael, Dixon, Jill, Missero, Caterina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376849/
https://www.ncbi.nlm.nih.gov/pubmed/22247000
http://dx.doi.org/10.1002/emmm.201100199

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