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β- but not γ-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia

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A mutation in the BRI2/ITM2b gene causes loss of BRI2 protein leading to familial Danish dementia (FDD). BRI2 deficiency of FDD provokes an increase in amyloid-β precursor protein (APP) processing since BRI2 is an inhibitor of APP proteolysis, and APP mediates the synaptic/memory deficits in FDD. AP...

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Detalles Bibliográficos
Autores principales:	Tamayev, Robert, Matsuda, Shuji, Arancio, Ottavio, D'Adamio, Luciano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	WILEY-VCH Verlag 2012
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376850/ https://www.ncbi.nlm.nih.gov/pubmed/22170863 http://dx.doi.org/10.1002/emmm.201100195

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