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Altered γ-secretase activity in mild cognitive impairment and Alzheimer's disease

We investigated why the cerebrospinal fluid (CSF) concentrations of Aβ42 are lower in mild cognitive impairment (MCI) and Alzheimer's disease (AD) patients. Because Aβ38/42 and Aβ40/43 are distinct product/precursor pairs, these four species in the CSF together should faithfully reflect the sta...

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Detalles Bibliográficos
Autores principales:	Kakuda, Nobuto, Shoji, Mikio, Arai, Hiroyuki, Furukawa, Katsutoshi, Ikeuchi, Takeshi, Akazawa, Kohei, Takami, Mako, Hatsuta, Hiroyuki, Murayama, Shigeo, Hashimoto, Yasuhiro, Miyajima, Masakazu, Arai, Hajime, Nagashima, Yu, Yamaguchi, Haruyasu, Kuwano, Ryozo, Nagaike, Kazuhiro, Ihara, Yasuo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	WILEY-VCH Verlag 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376855/ https://www.ncbi.nlm.nih.gov/pubmed/22354516 http://dx.doi.org/10.1002/emmm.201200214

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