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Molecular mechanisms of vascular effects of High-density lipoprotein: alterations in cardiovascular disease
Low high-density lipoprotein (HDL)-cholesterol levels are associated with an increased risk of coronary artery disease (CAD) and myocardial infarction, which has triggered the hypothesis that HDL, in contrast to low-density lipoprotein (LDL), acts as an anti-atherogenic lipoprotein. Moreover, experi...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
WILEY-VCH Verlag
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376856/ https://www.ncbi.nlm.nih.gov/pubmed/22431312 http://dx.doi.org/10.1002/emmm.201200224 |
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author | Besler, Christian Lüscher, Thomas F Landmesser, Ulf |
author_facet | Besler, Christian Lüscher, Thomas F Landmesser, Ulf |
author_sort | Besler, Christian |
collection | PubMed |
description | Low high-density lipoprotein (HDL)-cholesterol levels are associated with an increased risk of coronary artery disease (CAD) and myocardial infarction, which has triggered the hypothesis that HDL, in contrast to low-density lipoprotein (LDL), acts as an anti-atherogenic lipoprotein. Moreover, experimental studies have identified potential anti-atherogenic properties of HDL, including promotion of macrophage cholesterol efflux and direct endothelial-protective effects of HDL, such as stimulation of endothelial nitric oxide production and repair, anti-apoptotic, anti-inflammatory and anti-thrombotic properties. Studies in gene-targeted mice, however, have also indicated that increasing HDL-cholesterol plasma levels can either limit (e.g. apolipoprotein A-I) or accelerate (e.g. Scavenger receptor class B type I) atherosclerosis. Moreover, vascular effects of HDL have been observed to be heterogenous and are altered in patients with CAD or diabetes, a condition that has been termed ‘HDL dysfunction’. These alterations in biological functions of HDL may need to be taken into account for HDL-targeted therapies and considering raising of HDL-cholesterol levels alone is likely not sufficient in this respect. It will therefore be important to further determine, which biological functions of HDL are critical for its anti-atherosclerotic properties, as well as how these can be measured and targeted. |
format | Online Article Text |
id | pubmed-3376856 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | WILEY-VCH Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-33768562012-09-17 Molecular mechanisms of vascular effects of High-density lipoprotein: alterations in cardiovascular disease Besler, Christian Lüscher, Thomas F Landmesser, Ulf EMBO Mol Med Review Low high-density lipoprotein (HDL)-cholesterol levels are associated with an increased risk of coronary artery disease (CAD) and myocardial infarction, which has triggered the hypothesis that HDL, in contrast to low-density lipoprotein (LDL), acts as an anti-atherogenic lipoprotein. Moreover, experimental studies have identified potential anti-atherogenic properties of HDL, including promotion of macrophage cholesterol efflux and direct endothelial-protective effects of HDL, such as stimulation of endothelial nitric oxide production and repair, anti-apoptotic, anti-inflammatory and anti-thrombotic properties. Studies in gene-targeted mice, however, have also indicated that increasing HDL-cholesterol plasma levels can either limit (e.g. apolipoprotein A-I) or accelerate (e.g. Scavenger receptor class B type I) atherosclerosis. Moreover, vascular effects of HDL have been observed to be heterogenous and are altered in patients with CAD or diabetes, a condition that has been termed ‘HDL dysfunction’. These alterations in biological functions of HDL may need to be taken into account for HDL-targeted therapies and considering raising of HDL-cholesterol levels alone is likely not sufficient in this respect. It will therefore be important to further determine, which biological functions of HDL are critical for its anti-atherosclerotic properties, as well as how these can be measured and targeted. WILEY-VCH Verlag 2012-04 /pmc/articles/PMC3376856/ /pubmed/22431312 http://dx.doi.org/10.1002/emmm.201200224 Text en Copyright © 2012 EMBO Molecular Medicine |
spellingShingle | Review Besler, Christian Lüscher, Thomas F Landmesser, Ulf Molecular mechanisms of vascular effects of High-density lipoprotein: alterations in cardiovascular disease |
title | Molecular mechanisms of vascular effects of High-density lipoprotein: alterations in cardiovascular disease |
title_full | Molecular mechanisms of vascular effects of High-density lipoprotein: alterations in cardiovascular disease |
title_fullStr | Molecular mechanisms of vascular effects of High-density lipoprotein: alterations in cardiovascular disease |
title_full_unstemmed | Molecular mechanisms of vascular effects of High-density lipoprotein: alterations in cardiovascular disease |
title_short | Molecular mechanisms of vascular effects of High-density lipoprotein: alterations in cardiovascular disease |
title_sort | molecular mechanisms of vascular effects of high-density lipoprotein: alterations in cardiovascular disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376856/ https://www.ncbi.nlm.nih.gov/pubmed/22431312 http://dx.doi.org/10.1002/emmm.201200224 |
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