Investigation of a new tumor-associated glycosylated antigen as target for dendritic cell vaccination in pancreatic cancer

Glycoproteins, as valuable targets for dendritic cell (DC)-vaccination in cancers, remain an open question. Glycosylated structures, which are aberrantly modified during cancerisation, impact positively or negatively on glycoprotein immunogenicity. Here is presented an oncofetal glycovariant of bile...

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Autores principales: Béraud, Evelyne, Collignon, Aurélie, Franceschi, Cécile, Olive, Daniel, Lombardo, Dominique, Mas, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Mini Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376954/
https://www.ncbi.nlm.nih.gov/pubmed/22720212
http://dx.doi.org/10.4161/onci.1.1.18459
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author Béraud, Evelyne
Collignon, Aurélie
Franceschi, Cécile
Olive, Daniel
Lombardo, Dominique
Mas, Eric
author_facet Béraud, Evelyne
Collignon, Aurélie
Franceschi, Cécile
Olive, Daniel
Lombardo, Dominique
Mas, Eric
author_sort Béraud, Evelyne
collection PubMed
description Glycoproteins, as valuable targets for dendritic cell (DC)-vaccination in cancers, remain an open question. Glycosylated structures, which are aberrantly modified during cancerisation, impact positively or negatively on glycoprotein immunogenicity. Here is presented an oncofetal glycovariant of bile-salt-dependent-lipase, expressed on human tumoral pancreas and efficiently processed by DC’s, inducing T-lymphocyte activation.
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spelling pubmed-33769542012-06-20 Investigation of a new tumor-associated glycosylated antigen as target for dendritic cell vaccination in pancreatic cancer Béraud, Evelyne Collignon, Aurélie Franceschi, Cécile Olive, Daniel Lombardo, Dominique Mas, Eric Oncoimmunology Mini Review Glycoproteins, as valuable targets for dendritic cell (DC)-vaccination in cancers, remain an open question. Glycosylated structures, which are aberrantly modified during cancerisation, impact positively or negatively on glycoprotein immunogenicity. Here is presented an oncofetal glycovariant of bile-salt-dependent-lipase, expressed on human tumoral pancreas and efficiently processed by DC’s, inducing T-lymphocyte activation. Landes Bioscience 2012-01-01 /pmc/articles/PMC3376954/ /pubmed/22720212 http://dx.doi.org/10.4161/onci.1.1.18459 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Mini Review
Béraud, Evelyne
Collignon, Aurélie
Franceschi, Cécile
Olive, Daniel
Lombardo, Dominique
Mas, Eric
Investigation of a new tumor-associated glycosylated antigen as target for dendritic cell vaccination in pancreatic cancer
title Investigation of a new tumor-associated glycosylated antigen as target for dendritic cell vaccination in pancreatic cancer
title_full Investigation of a new tumor-associated glycosylated antigen as target for dendritic cell vaccination in pancreatic cancer
title_fullStr Investigation of a new tumor-associated glycosylated antigen as target for dendritic cell vaccination in pancreatic cancer
title_full_unstemmed Investigation of a new tumor-associated glycosylated antigen as target for dendritic cell vaccination in pancreatic cancer
title_short Investigation of a new tumor-associated glycosylated antigen as target for dendritic cell vaccination in pancreatic cancer
title_sort investigation of a new tumor-associated glycosylated antigen as target for dendritic cell vaccination in pancreatic cancer
topic Mini Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376954/
https://www.ncbi.nlm.nih.gov/pubmed/22720212
http://dx.doi.org/10.4161/onci.1.1.18459
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