NK cells sense tumors, course of disease and treatments: Consequences for NK-based therapies

The recent findings on NK activation indicate that these cells are important antitumor effectors. NK cells participate in the graft-vs.-leukemia effect to control the relapse in leukemic patients transplanted with allogeneic hematopoietic stem cells. In various tumors, correlation between NK cell in...

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Autores principales: Fregni, Giulia, Perier, Aurélie, Avril, Marie-Françoise, Caignard, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376977/
https://www.ncbi.nlm.nih.gov/pubmed/22720210
http://dx.doi.org/10.4161/onci.1.1.18312
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author Fregni, Giulia
Perier, Aurélie
Avril, Marie-Françoise
Caignard, Anne
author_facet Fregni, Giulia
Perier, Aurélie
Avril, Marie-Françoise
Caignard, Anne
author_sort Fregni, Giulia
collection PubMed
description The recent findings on NK activation indicate that these cells are important antitumor effectors. NK cells participate in the graft-vs.-leukemia effect to control the relapse in leukemic patients transplanted with allogeneic hematopoietic stem cells. In various tumors, correlation between NK cell infiltrates and prognosis were reported. However, tumor-infiltrating NK cells are yet poorly characterized. We here summarize our results and the recent studies of the literature on tumor-infiltrating NK cells, and discuss the impact of these novel insights into NK cell responses against tumors for the design of NK cell-based therapies.
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spelling pubmed-33769772012-06-20 NK cells sense tumors, course of disease and treatments: Consequences for NK-based therapies Fregni, Giulia Perier, Aurélie Avril, Marie-Françoise Caignard, Anne Oncoimmunology Review The recent findings on NK activation indicate that these cells are important antitumor effectors. NK cells participate in the graft-vs.-leukemia effect to control the relapse in leukemic patients transplanted with allogeneic hematopoietic stem cells. In various tumors, correlation between NK cell infiltrates and prognosis were reported. However, tumor-infiltrating NK cells are yet poorly characterized. We here summarize our results and the recent studies of the literature on tumor-infiltrating NK cells, and discuss the impact of these novel insights into NK cell responses against tumors for the design of NK cell-based therapies. Landes Bioscience 2012-01-01 /pmc/articles/PMC3376977/ /pubmed/22720210 http://dx.doi.org/10.4161/onci.1.1.18312 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Review
Fregni, Giulia
Perier, Aurélie
Avril, Marie-Françoise
Caignard, Anne
NK cells sense tumors, course of disease and treatments: Consequences for NK-based therapies
title NK cells sense tumors, course of disease and treatments: Consequences for NK-based therapies
title_full NK cells sense tumors, course of disease and treatments: Consequences for NK-based therapies
title_fullStr NK cells sense tumors, course of disease and treatments: Consequences for NK-based therapies
title_full_unstemmed NK cells sense tumors, course of disease and treatments: Consequences for NK-based therapies
title_short NK cells sense tumors, course of disease and treatments: Consequences for NK-based therapies
title_sort nk cells sense tumors, course of disease and treatments: consequences for nk-based therapies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376977/
https://www.ncbi.nlm.nih.gov/pubmed/22720210
http://dx.doi.org/10.4161/onci.1.1.18312
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