Chronic liver inflammation dominated by interferon-γ can prevent hepatocarcinogenesis

Inflammation is a major stimulus for carcinogenesis; however inflammation can also inhibit tumor growth and deplete malignant cells. The differences between cancer-promoting and cancer-inhibitory inflammation are not clear. We identified Interferon-γ as a major mediator of cancer-inhibitory inflamma...

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Detalles Bibliográficos
Autores principales: Schrader, Jörg, Herkel, Johannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376979/
https://www.ncbi.nlm.nih.gov/pubmed/22720249
http://dx.doi.org/10.4161/onci.1.2.18114
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author Schrader, Jörg
Herkel, Johannes
author_facet Schrader, Jörg
Herkel, Johannes
author_sort Schrader, Jörg
collection PubMed
description Inflammation is a major stimulus for carcinogenesis; however inflammation can also inhibit tumor growth and deplete malignant cells. The differences between cancer-promoting and cancer-inhibitory inflammation are not clear. We identified Interferon-γ as a major mediator of cancer-inhibitory inflammation that promotes anti-cancer immunity in the liver and sensitizes malignant hepatocytes for apoptosis.
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spelling pubmed-33769792012-06-20 Chronic liver inflammation dominated by interferon-γ can prevent hepatocarcinogenesis Schrader, Jörg Herkel, Johannes Oncoimmunology Author's View Inflammation is a major stimulus for carcinogenesis; however inflammation can also inhibit tumor growth and deplete malignant cells. The differences between cancer-promoting and cancer-inhibitory inflammation are not clear. We identified Interferon-γ as a major mediator of cancer-inhibitory inflammation that promotes anti-cancer immunity in the liver and sensitizes malignant hepatocytes for apoptosis. Landes Bioscience 2012-03-01 /pmc/articles/PMC3376979/ /pubmed/22720249 http://dx.doi.org/10.4161/onci.1.2.18114 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Schrader, Jörg
Herkel, Johannes
Chronic liver inflammation dominated by interferon-γ can prevent hepatocarcinogenesis
title Chronic liver inflammation dominated by interferon-γ can prevent hepatocarcinogenesis
title_full Chronic liver inflammation dominated by interferon-γ can prevent hepatocarcinogenesis
title_fullStr Chronic liver inflammation dominated by interferon-γ can prevent hepatocarcinogenesis
title_full_unstemmed Chronic liver inflammation dominated by interferon-γ can prevent hepatocarcinogenesis
title_short Chronic liver inflammation dominated by interferon-γ can prevent hepatocarcinogenesis
title_sort chronic liver inflammation dominated by interferon-γ can prevent hepatocarcinogenesis
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376979/
https://www.ncbi.nlm.nih.gov/pubmed/22720249
http://dx.doi.org/10.4161/onci.1.2.18114
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