FOXO3: A master switch for regulating tolerance and immunity in dendritic cells

Recent findings demonstrate that dendritic cells in prostate tumors induce immune tolerance in tumor antigen-specific CD8(+) T cells. We propose that DC tolerogenicity can be regulated by expression of Foxo3; silencing Foxo3 expression enhances anti-tumor immune responses and renders FOXO3 a potenti...

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Detalles Bibliográficos
Autores principales: Watkins, Stephanie K., Hurwitz, Arthur A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376981/
https://www.ncbi.nlm.nih.gov/pubmed/22720261
http://dx.doi.org/10.4161/onci.1.2.18241
Descripción
Sumario:Recent findings demonstrate that dendritic cells in prostate tumors induce immune tolerance in tumor antigen-specific CD8(+) T cells. We propose that DC tolerogenicity can be regulated by expression of Foxo3; silencing Foxo3 expression enhances anti-tumor immune responses and renders FOXO3 a potential target for immunotherapy.

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