FOXO3: A master switch for regulating tolerance and immunity in dendritic cells

Recent findings demonstrate that dendritic cells in prostate tumors induce immune tolerance in tumor antigen-specific CD8(+) T cells. We propose that DC tolerogenicity can be regulated by expression of Foxo3; silencing Foxo3 expression enhances anti-tumor immune responses and renders FOXO3 a potenti...

Descripción completa

Detalles Bibliográficos
Autores principales: Watkins, Stephanie K., Hurwitz, Arthur A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376981/
https://www.ncbi.nlm.nih.gov/pubmed/22720261
http://dx.doi.org/10.4161/onci.1.2.18241
_version_ 1782235895631446016
author Watkins, Stephanie K.
Hurwitz, Arthur A.
author_facet Watkins, Stephanie K.
Hurwitz, Arthur A.
author_sort Watkins, Stephanie K.
collection PubMed
description Recent findings demonstrate that dendritic cells in prostate tumors induce immune tolerance in tumor antigen-specific CD8(+) T cells. We propose that DC tolerogenicity can be regulated by expression of Foxo3; silencing Foxo3 expression enhances anti-tumor immune responses and renders FOXO3 a potential target for immunotherapy.
format Online
Article
Text
id pubmed-3376981
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Landes Bioscience
record_format MEDLINE/PubMed
spelling pubmed-33769812012-06-20 FOXO3: A master switch for regulating tolerance and immunity in dendritic cells Watkins, Stephanie K. Hurwitz, Arthur A. Oncoimmunology Author's View Recent findings demonstrate that dendritic cells in prostate tumors induce immune tolerance in tumor antigen-specific CD8(+) T cells. We propose that DC tolerogenicity can be regulated by expression of Foxo3; silencing Foxo3 expression enhances anti-tumor immune responses and renders FOXO3 a potential target for immunotherapy. Landes Bioscience 2012-03-01 /pmc/articles/PMC3376981/ /pubmed/22720261 http://dx.doi.org/10.4161/onci.1.2.18241 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Watkins, Stephanie K.
Hurwitz, Arthur A.
FOXO3: A master switch for regulating tolerance and immunity in dendritic cells
title FOXO3: A master switch for regulating tolerance and immunity in dendritic cells
title_full FOXO3: A master switch for regulating tolerance and immunity in dendritic cells
title_fullStr FOXO3: A master switch for regulating tolerance and immunity in dendritic cells
title_full_unstemmed FOXO3: A master switch for regulating tolerance and immunity in dendritic cells
title_short FOXO3: A master switch for regulating tolerance and immunity in dendritic cells
title_sort foxo3: a master switch for regulating tolerance and immunity in dendritic cells
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376981/
https://www.ncbi.nlm.nih.gov/pubmed/22720261
http://dx.doi.org/10.4161/onci.1.2.18241
work_keys_str_mv AT watkinsstephaniek foxo3amasterswitchforregulatingtoleranceandimmunityindendriticcells
AT hurwitzarthura foxo3amasterswitchforregulatingtoleranceandimmunityindendriticcells

Ejemplares similares