Host CD73 impairs anti-tumor immunity

The enzymatic activity of CD73 produces immune-suppressing adenosine. In CD73 deficient hosts, tumor growth and tumor infiltration by Tregs and type 2 immunosuppressive macrophages is reduced. Pharmacological inhibition of CD73 in wild-type mice has similar tumor-suppressing effects. Host CD73 on le...

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Detalles Bibliográficos
Autores principales: Salmi, Marko, Jalkanen, Sirpa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376983/
https://www.ncbi.nlm.nih.gov/pubmed/22720259
http://dx.doi.org/10.4161/onci.1.2.18310
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author Salmi, Marko
Jalkanen, Sirpa
author_facet Salmi, Marko
Jalkanen, Sirpa
author_sort Salmi, Marko
collection PubMed
description The enzymatic activity of CD73 produces immune-suppressing adenosine. In CD73 deficient hosts, tumor growth and tumor infiltration by Tregs and type 2 immunosuppressive macrophages is reduced. Pharmacological inhibition of CD73 in wild-type mice has similar tumor-suppressing effects. Host CD73 on leukocytes and endothelial cells is thus detrimental for the anti-tumor immunity.
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spelling pubmed-33769832012-06-20 Host CD73 impairs anti-tumor immunity Salmi, Marko Jalkanen, Sirpa Oncoimmunology Author's View The enzymatic activity of CD73 produces immune-suppressing adenosine. In CD73 deficient hosts, tumor growth and tumor infiltration by Tregs and type 2 immunosuppressive macrophages is reduced. Pharmacological inhibition of CD73 in wild-type mice has similar tumor-suppressing effects. Host CD73 on leukocytes and endothelial cells is thus detrimental for the anti-tumor immunity. Landes Bioscience 2012-03-01 /pmc/articles/PMC3376983/ /pubmed/22720259 http://dx.doi.org/10.4161/onci.1.2.18310 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Salmi, Marko
Jalkanen, Sirpa
Host CD73 impairs anti-tumor immunity
title Host CD73 impairs anti-tumor immunity
title_full Host CD73 impairs anti-tumor immunity
title_fullStr Host CD73 impairs anti-tumor immunity
title_full_unstemmed Host CD73 impairs anti-tumor immunity
title_short Host CD73 impairs anti-tumor immunity
title_sort host cd73 impairs anti-tumor immunity
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376983/
https://www.ncbi.nlm.nih.gov/pubmed/22720259
http://dx.doi.org/10.4161/onci.1.2.18310
work_keys_str_mv AT salmimarko hostcd73impairsantitumorimmunity
AT jalkanensirpa hostcd73impairsantitumorimmunity

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