New insights into the role of NK cells in cancer immunotherapy

Repetitive infusions of ex vivo expanded NK cells induced antitumor T-cell responses in a metastatic lung cancer mouse model. These were further potentiated by Treg depletion. Thus the combination of NK cell-based immunotherapy with other treatment modalities in the direction of adaptive response en...

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Detalles Bibliográficos
Autores principales: Salagianni, Maria, Baxevanis, Constantin N., Papamichail, Michael, Perez, Sonia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376993/
https://www.ncbi.nlm.nih.gov/pubmed/22720243
http://dx.doi.org/10.4161/onci.1.2.18398
Descripción
Sumario:Repetitive infusions of ex vivo expanded NK cells induced antitumor T-cell responses in a metastatic lung cancer mouse model. These were further potentiated by Treg depletion. Thus the combination of NK cell-based immunotherapy with other treatment modalities in the direction of adaptive response enhancement might promote long lasting antitumor immunity.

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