New insights into the role of NK cells in cancer immunotherapy

Repetitive infusions of ex vivo expanded NK cells induced antitumor T-cell responses in a metastatic lung cancer mouse model. These were further potentiated by Treg depletion. Thus the combination of NK cell-based immunotherapy with other treatment modalities in the direction of adaptive response en...

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Detalles Bibliográficos
Autores principales: Salagianni, Maria, Baxevanis, Constantin N., Papamichail, Michael, Perez, Sonia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376993/
https://www.ncbi.nlm.nih.gov/pubmed/22720243
http://dx.doi.org/10.4161/onci.1.2.18398
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author Salagianni, Maria
Baxevanis, Constantin N.
Papamichail, Michael
Perez, Sonia A.
author_facet Salagianni, Maria
Baxevanis, Constantin N.
Papamichail, Michael
Perez, Sonia A.
author_sort Salagianni, Maria
collection PubMed
description Repetitive infusions of ex vivo expanded NK cells induced antitumor T-cell responses in a metastatic lung cancer mouse model. These were further potentiated by Treg depletion. Thus the combination of NK cell-based immunotherapy with other treatment modalities in the direction of adaptive response enhancement might promote long lasting antitumor immunity.
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spelling pubmed-33769932012-06-20 New insights into the role of NK cells in cancer immunotherapy Salagianni, Maria Baxevanis, Constantin N. Papamichail, Michael Perez, Sonia A. Oncoimmunology Author's View Repetitive infusions of ex vivo expanded NK cells induced antitumor T-cell responses in a metastatic lung cancer mouse model. These were further potentiated by Treg depletion. Thus the combination of NK cell-based immunotherapy with other treatment modalities in the direction of adaptive response enhancement might promote long lasting antitumor immunity. Landes Bioscience 2012-03-01 /pmc/articles/PMC3376993/ /pubmed/22720243 http://dx.doi.org/10.4161/onci.1.2.18398 Text en Copyright © 2011 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Salagianni, Maria
Baxevanis, Constantin N.
Papamichail, Michael
Perez, Sonia A.
New insights into the role of NK cells in cancer immunotherapy
title New insights into the role of NK cells in cancer immunotherapy
title_full New insights into the role of NK cells in cancer immunotherapy
title_fullStr New insights into the role of NK cells in cancer immunotherapy
title_full_unstemmed New insights into the role of NK cells in cancer immunotherapy
title_short New insights into the role of NK cells in cancer immunotherapy
title_sort new insights into the role of nk cells in cancer immunotherapy
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376993/
https://www.ncbi.nlm.nih.gov/pubmed/22720243
http://dx.doi.org/10.4161/onci.1.2.18398
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