STATing the importance of immune modulation by platinum chemotherapeutics

Platinum-based anticancer drugs enhance the immunostimulatory potential of DCs and decrease the immunosuppressive capacity of tumor cells. This immunomodulatory ability is based on the inhibition of STAT6-mediated expression of co-inhibitory molecule PD-L2 and opens up the possibility of using these...

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Detalles Bibliográficos
Autores principales: Hato, Stanleyson V., de Vries, I. Jolanda M., Lesterhuis, W. Joost
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376994/
https://www.ncbi.nlm.nih.gov/pubmed/22720254
http://dx.doi.org/10.4161/onci.1.2.18126
Descripción
Sumario:Platinum-based anticancer drugs enhance the immunostimulatory potential of DCs and decrease the immunosuppressive capacity of tumor cells. This immunomodulatory ability is based on the inhibition of STAT6-mediated expression of co-inhibitory molecule PD-L2 and opens up the possibility of using these drugs in combination with other immunostimulatory compounds.

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