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STATing the importance of immune modulation by platinum chemotherapeutics
Platinum-based anticancer drugs enhance the immunostimulatory potential of DCs and decrease the immunosuppressive capacity of tumor cells. This immunomodulatory ability is based on the inhibition of STAT6-mediated expression of co-inhibitory molecule PD-L2 and opens up the possibility of using these...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Landes Bioscience
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376994/ https://www.ncbi.nlm.nih.gov/pubmed/22720254 http://dx.doi.org/10.4161/onci.1.2.18126 |
| _version_ | 1782235898447921152 |
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| author | Hato, Stanleyson V. de Vries, I. Jolanda M. Lesterhuis, W. Joost |
| author_facet | Hato, Stanleyson V. de Vries, I. Jolanda M. Lesterhuis, W. Joost |
| author_sort | Hato, Stanleyson V. |
| collection | PubMed |
| description | Platinum-based anticancer drugs enhance the immunostimulatory potential of DCs and decrease the immunosuppressive capacity of tumor cells. This immunomodulatory ability is based on the inhibition of STAT6-mediated expression of co-inhibitory molecule PD-L2 and opens up the possibility of using these drugs in combination with other immunostimulatory compounds. |
| format | Online Article Text |
| id | pubmed-3376994 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2012 |
| publisher | Landes Bioscience |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-33769942012-06-20 STATing the importance of immune modulation by platinum chemotherapeutics Hato, Stanleyson V. de Vries, I. Jolanda M. Lesterhuis, W. Joost Oncoimmunology Author's View Platinum-based anticancer drugs enhance the immunostimulatory potential of DCs and decrease the immunosuppressive capacity of tumor cells. This immunomodulatory ability is based on the inhibition of STAT6-mediated expression of co-inhibitory molecule PD-L2 and opens up the possibility of using these drugs in combination with other immunostimulatory compounds. Landes Bioscience 2012-03-01 /pmc/articles/PMC3376994/ /pubmed/22720254 http://dx.doi.org/10.4161/onci.1.2.18126 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
| spellingShingle | Author's View Hato, Stanleyson V. de Vries, I. Jolanda M. Lesterhuis, W. Joost STATing the importance of immune modulation by platinum chemotherapeutics |
| title | STATing the importance of immune modulation by platinum chemotherapeutics |
| title_full | STATing the importance of immune modulation by platinum chemotherapeutics |
| title_fullStr | STATing the importance of immune modulation by platinum chemotherapeutics |
| title_full_unstemmed | STATing the importance of immune modulation by platinum chemotherapeutics |
| title_short | STATing the importance of immune modulation by platinum chemotherapeutics |
| title_sort | stating the importance of immune modulation by platinum chemotherapeutics |
| topic | Author's View |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376994/ https://www.ncbi.nlm.nih.gov/pubmed/22720254 http://dx.doi.org/10.4161/onci.1.2.18126 |
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