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Tumor immune escape in acute myeloid leukemia: Class II-associated invariant chain peptide expression as result of deficient antigen presentation
In this overview, we discuss the role of class II-associated invariant chain peptide (CLIP) in acute myeloid leukemia (AML), one of the few tumors expressing HLA class II. The clinical impact, function and regulation of CLIP expression on leukemic cells is addressed, indicating its potential as immu...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Landes Bioscience
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376995/ https://www.ncbi.nlm.nih.gov/pubmed/22720245 http://dx.doi.org/10.4161/onci.1.2.18100 |
| _version_ | 1782235898674413568 |
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| author | van Luijn, Marvin M. Chamuleau, Martine E.D. Ossenkoppele, Gert J. van de Loosdrecht, Arjan A. Marieke van Ham, S. |
| author_facet | van Luijn, Marvin M. Chamuleau, Martine E.D. Ossenkoppele, Gert J. van de Loosdrecht, Arjan A. Marieke van Ham, S. |
| author_sort | van Luijn, Marvin M. |
| collection | PubMed |
| description | In this overview, we discuss the role of class II-associated invariant chain peptide (CLIP) in acute myeloid leukemia (AML), one of the few tumors expressing HLA class II. The clinical impact, function and regulation of CLIP expression on leukemic cells is addressed, indicating its potential as immunotherapeutic target in AML. |
| format | Online Article Text |
| id | pubmed-3376995 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2012 |
| publisher | Landes Bioscience |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-33769952012-06-20 Tumor immune escape in acute myeloid leukemia: Class II-associated invariant chain peptide expression as result of deficient antigen presentation van Luijn, Marvin M. Chamuleau, Martine E.D. Ossenkoppele, Gert J. van de Loosdrecht, Arjan A. Marieke van Ham, S. Oncoimmunology Author's View In this overview, we discuss the role of class II-associated invariant chain peptide (CLIP) in acute myeloid leukemia (AML), one of the few tumors expressing HLA class II. The clinical impact, function and regulation of CLIP expression on leukemic cells is addressed, indicating its potential as immunotherapeutic target in AML. Landes Bioscience 2012-03-01 /pmc/articles/PMC3376995/ /pubmed/22720245 http://dx.doi.org/10.4161/onci.1.2.18100 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
| spellingShingle | Author's View van Luijn, Marvin M. Chamuleau, Martine E.D. Ossenkoppele, Gert J. van de Loosdrecht, Arjan A. Marieke van Ham, S. Tumor immune escape in acute myeloid leukemia: Class II-associated invariant chain peptide expression as result of deficient antigen presentation |
| title | Tumor immune escape in acute myeloid leukemia: Class II-associated invariant chain peptide expression as result of deficient antigen presentation |
| title_full | Tumor immune escape in acute myeloid leukemia: Class II-associated invariant chain peptide expression as result of deficient antigen presentation |
| title_fullStr | Tumor immune escape in acute myeloid leukemia: Class II-associated invariant chain peptide expression as result of deficient antigen presentation |
| title_full_unstemmed | Tumor immune escape in acute myeloid leukemia: Class II-associated invariant chain peptide expression as result of deficient antigen presentation |
| title_short | Tumor immune escape in acute myeloid leukemia: Class II-associated invariant chain peptide expression as result of deficient antigen presentation |
| title_sort | tumor immune escape in acute myeloid leukemia: class ii-associated invariant chain peptide expression as result of deficient antigen presentation |
| topic | Author's View |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376995/ https://www.ncbi.nlm.nih.gov/pubmed/22720245 http://dx.doi.org/10.4161/onci.1.2.18100 |
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