Modulation of DNA repair genes induced by TLR9 agonists: A strategy to eliminate “altered” cells?

We provided evidence that the TLR9 engagement of innate immune cells present in the tumor microenvironment by CpG-oligodeoxynucleotide (CpG-ODN) induces down-modulation of DNA repair gene expression in tumor cells, sensitizing cancer cells to DNA-damaging chemotherapy. These findings expand the bene...

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Autores principales: Sommariva, Michele, De Cecco, Loris, Tagliabue, Elda, Balsari, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377000/
https://www.ncbi.nlm.nih.gov/pubmed/22720263
http://dx.doi.org/10.4161/onci.1.2.18343
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author Sommariva, Michele
De Cecco, Loris
Tagliabue, Elda
Balsari, Andrea
author_facet Sommariva, Michele
De Cecco, Loris
Tagliabue, Elda
Balsari, Andrea
author_sort Sommariva, Michele
collection PubMed
description We provided evidence that the TLR9 engagement of innate immune cells present in the tumor microenvironment by CpG-oligodeoxynucleotide (CpG-ODN) induces down-modulation of DNA repair gene expression in tumor cells, sensitizing cancer cells to DNA-damaging chemotherapy. These findings expand the benefits of CpG-ODN therapy beyond induction of a strong immune response.
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spelling pubmed-33770002012-06-20 Modulation of DNA repair genes induced by TLR9 agonists: A strategy to eliminate “altered” cells? Sommariva, Michele De Cecco, Loris Tagliabue, Elda Balsari, Andrea Oncoimmunology Author's View We provided evidence that the TLR9 engagement of innate immune cells present in the tumor microenvironment by CpG-oligodeoxynucleotide (CpG-ODN) induces down-modulation of DNA repair gene expression in tumor cells, sensitizing cancer cells to DNA-damaging chemotherapy. These findings expand the benefits of CpG-ODN therapy beyond induction of a strong immune response. Landes Bioscience 2012-03-01 /pmc/articles/PMC3377000/ /pubmed/22720263 http://dx.doi.org/10.4161/onci.1.2.18343 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Sommariva, Michele
De Cecco, Loris
Tagliabue, Elda
Balsari, Andrea
Modulation of DNA repair genes induced by TLR9 agonists: A strategy to eliminate “altered” cells?
title Modulation of DNA repair genes induced by TLR9 agonists: A strategy to eliminate “altered” cells?
title_full Modulation of DNA repair genes induced by TLR9 agonists: A strategy to eliminate “altered” cells?
title_fullStr Modulation of DNA repair genes induced by TLR9 agonists: A strategy to eliminate “altered” cells?
title_full_unstemmed Modulation of DNA repair genes induced by TLR9 agonists: A strategy to eliminate “altered” cells?
title_short Modulation of DNA repair genes induced by TLR9 agonists: A strategy to eliminate “altered” cells?
title_sort modulation of dna repair genes induced by tlr9 agonists: a strategy to eliminate “altered” cells?
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377000/
https://www.ncbi.nlm.nih.gov/pubmed/22720263
http://dx.doi.org/10.4161/onci.1.2.18343
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