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Modulation of DNA repair genes induced by TLR9 agonists: A strategy to eliminate “altered” cells?

We provided evidence that the TLR9 engagement of innate immune cells present in the tumor microenvironment by CpG-oligodeoxynucleotide (CpG-ODN) induces down-modulation of DNA repair gene expression in tumor cells, sensitizing cancer cells to DNA-damaging chemotherapy. These findings expand the bene...

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Detalles Bibliográficos
Autores principales:	Sommariva, Michele, De Cecco, Loris, Tagliabue, Elda, Balsari, Andrea
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Landes Bioscience 2012
Materias:	Author's View
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377000/ https://www.ncbi.nlm.nih.gov/pubmed/22720263 http://dx.doi.org/10.4161/onci.1.2.18343

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