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A novel role for granzymes in anti-tumor immunity
The cytotoxic properties of granzymes are well established, though recent publications suggest additional roles for granzymes in immunity. We demonstrated that granzymes can act as regulators of cross-presentation by dendritic cells by inducing critical “eat-me” signals on the dying tumor cell, resu...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Landes Bioscience
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377003/ https://www.ncbi.nlm.nih.gov/pubmed/22720248 http://dx.doi.org/10.4161/onci.1.2.18102 |
| _version_ | 1782235900517810176 |
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| author | Hoves, Sabine Sutton, Vivien R. Trapani, Joseph A. |
| author_facet | Hoves, Sabine Sutton, Vivien R. Trapani, Joseph A. |
| author_sort | Hoves, Sabine |
| collection | PubMed |
| description | The cytotoxic properties of granzymes are well established, though recent publications suggest additional roles for granzymes in immunity. We demonstrated that granzymes can act as regulators of cross-presentation by dendritic cells by inducing critical “eat-me” signals on the dying tumor cell, resulting in efficient phagocytosis of cell-associated tumor antigen. |
| format | Online Article Text |
| id | pubmed-3377003 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2012 |
| publisher | Landes Bioscience |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-33770032012-06-20 A novel role for granzymes in anti-tumor immunity Hoves, Sabine Sutton, Vivien R. Trapani, Joseph A. Oncoimmunology Author's View The cytotoxic properties of granzymes are well established, though recent publications suggest additional roles for granzymes in immunity. We demonstrated that granzymes can act as regulators of cross-presentation by dendritic cells by inducing critical “eat-me” signals on the dying tumor cell, resulting in efficient phagocytosis of cell-associated tumor antigen. Landes Bioscience 2012-03-01 /pmc/articles/PMC3377003/ /pubmed/22720248 http://dx.doi.org/10.4161/onci.1.2.18102 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
| spellingShingle | Author's View Hoves, Sabine Sutton, Vivien R. Trapani, Joseph A. A novel role for granzymes in anti-tumor immunity |
| title | A novel role for granzymes in anti-tumor immunity |
| title_full | A novel role for granzymes in anti-tumor immunity |
| title_fullStr | A novel role for granzymes in anti-tumor immunity |
| title_full_unstemmed | A novel role for granzymes in anti-tumor immunity |
| title_short | A novel role for granzymes in anti-tumor immunity |
| title_sort | novel role for granzymes in anti-tumor immunity |
| topic | Author's View |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377003/ https://www.ncbi.nlm.nih.gov/pubmed/22720248 http://dx.doi.org/10.4161/onci.1.2.18102 |
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