Tumor microenvironment in NSCLC suppresses NK cells function

NK cells, which contribute to tumor immunosurveillance, are present in the microenvironment of Non-Small-Cell Lung Carcinoma. However, they display strongly altered phenotype with decreased expression of NKp30, NKp80, DNAM-1, CD16 and ILT2, and impaired cytotoxic functions. The possible mechanisms l...

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Autores principales: Cremer, Isabelle, Fridman, Wolf Herman, Sautès-Fridman, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377004/
https://www.ncbi.nlm.nih.gov/pubmed/22720258
http://dx.doi.org/10.4161/onci.1.2.18309
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author Cremer, Isabelle
Fridman, Wolf Herman
Sautès-Fridman, Catherine
author_facet Cremer, Isabelle
Fridman, Wolf Herman
Sautès-Fridman, Catherine
author_sort Cremer, Isabelle
collection PubMed
description NK cells, which contribute to tumor immunosurveillance, are present in the microenvironment of Non-Small-Cell Lung Carcinoma. However, they display strongly altered phenotype with decreased expression of NKp30, NKp80, DNAM-1, CD16 and ILT2, and impaired cytotoxic functions. The possible mechanisms leading to these defects are discussed.
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spelling pubmed-33770042012-06-20 Tumor microenvironment in NSCLC suppresses NK cells function Cremer, Isabelle Fridman, Wolf Herman Sautès-Fridman, Catherine Oncoimmunology Author's View NK cells, which contribute to tumor immunosurveillance, are present in the microenvironment of Non-Small-Cell Lung Carcinoma. However, they display strongly altered phenotype with decreased expression of NKp30, NKp80, DNAM-1, CD16 and ILT2, and impaired cytotoxic functions. The possible mechanisms leading to these defects are discussed. Landes Bioscience 2012-03-01 /pmc/articles/PMC3377004/ /pubmed/22720258 http://dx.doi.org/10.4161/onci.1.2.18309 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Cremer, Isabelle
Fridman, Wolf Herman
Sautès-Fridman, Catherine
Tumor microenvironment in NSCLC suppresses NK cells function
title Tumor microenvironment in NSCLC suppresses NK cells function
title_full Tumor microenvironment in NSCLC suppresses NK cells function
title_fullStr Tumor microenvironment in NSCLC suppresses NK cells function
title_full_unstemmed Tumor microenvironment in NSCLC suppresses NK cells function
title_short Tumor microenvironment in NSCLC suppresses NK cells function
title_sort tumor microenvironment in nsclc suppresses nk cells function
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377004/
https://www.ncbi.nlm.nih.gov/pubmed/22720258
http://dx.doi.org/10.4161/onci.1.2.18309
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