Imatinib mesylate can help to direct natural immunity toward an anti-leukemic reactivity by acting on the bone marrow microenvironment

We discuss our recent findings on the increase, in chronic myeloid leukemia patients treated with imatinib, of B1 lymphocytes producing IgM anti-O-linked sugars expressed by leukemic cells, paralleled by increased B-stimulating cytokines. We propose that one important effect of imatinib treatment is...

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Detalles Bibliográficos
Autores principales: Poggi, Alessandro, Zocchi, Maria Raffaella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377005/
https://www.ncbi.nlm.nih.gov/pubmed/22720246
http://dx.doi.org/10.4161/onci.1.2.18112
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author Poggi, Alessandro
Zocchi, Maria Raffaella
author_facet Poggi, Alessandro
Zocchi, Maria Raffaella
author_sort Poggi, Alessandro
collection PubMed
description We discuss our recent findings on the increase, in chronic myeloid leukemia patients treated with imatinib, of B1 lymphocytes producing IgM anti-O-linked sugars expressed by leukemic cells, paralleled by increased B-stimulating cytokines. We propose that one important effect of imatinib treatment is due to the remodelling of bone marrow microenvironment.
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spelling pubmed-33770052012-06-20 Imatinib mesylate can help to direct natural immunity toward an anti-leukemic reactivity by acting on the bone marrow microenvironment Poggi, Alessandro Zocchi, Maria Raffaella Oncoimmunology Author's View We discuss our recent findings on the increase, in chronic myeloid leukemia patients treated with imatinib, of B1 lymphocytes producing IgM anti-O-linked sugars expressed by leukemic cells, paralleled by increased B-stimulating cytokines. We propose that one important effect of imatinib treatment is due to the remodelling of bone marrow microenvironment. Landes Bioscience 2012-03-01 /pmc/articles/PMC3377005/ /pubmed/22720246 http://dx.doi.org/10.4161/onci.1.2.18112 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Poggi, Alessandro
Zocchi, Maria Raffaella
Imatinib mesylate can help to direct natural immunity toward an anti-leukemic reactivity by acting on the bone marrow microenvironment
title Imatinib mesylate can help to direct natural immunity toward an anti-leukemic reactivity by acting on the bone marrow microenvironment
title_full Imatinib mesylate can help to direct natural immunity toward an anti-leukemic reactivity by acting on the bone marrow microenvironment
title_fullStr Imatinib mesylate can help to direct natural immunity toward an anti-leukemic reactivity by acting on the bone marrow microenvironment
title_full_unstemmed Imatinib mesylate can help to direct natural immunity toward an anti-leukemic reactivity by acting on the bone marrow microenvironment
title_short Imatinib mesylate can help to direct natural immunity toward an anti-leukemic reactivity by acting on the bone marrow microenvironment
title_sort imatinib mesylate can help to direct natural immunity toward an anti-leukemic reactivity by acting on the bone marrow microenvironment
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377005/
https://www.ncbi.nlm.nih.gov/pubmed/22720246
http://dx.doi.org/10.4161/onci.1.2.18112
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