Survivin the battle against immunosuppression

Improving on the limited success of cancer immunotherapy requires new approaches to inhibit immunosuppressive pathways initiated by tumor cells to “escape” protective immunity. One unique approach utilizes Salmonella for systemic delivery of inhibitory RNA, targeting the immunosuppressive molecule S...

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Detalles Bibliográficos
Autores principales: Manuel, Edwin R., Blache, Céline A., Ellenhorn, Joshua D.I., Diamond, Don J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377007/
https://www.ncbi.nlm.nih.gov/pubmed/22720256
http://dx.doi.org/10.4161/onci.1.2.18180
Descripción
Sumario:Improving on the limited success of cancer immunotherapy requires new approaches to inhibit immunosuppressive pathways initiated by tumor cells to “escape” protective immunity. One unique approach utilizes Salmonella for systemic delivery of inhibitory RNA, targeting the immunosuppressive molecule Stat3, and a Survivin vaccine to suppress growth of aggressive murine tumors.

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