Survivin the battle against immunosuppression

Improving on the limited success of cancer immunotherapy requires new approaches to inhibit immunosuppressive pathways initiated by tumor cells to “escape” protective immunity. One unique approach utilizes Salmonella for systemic delivery of inhibitory RNA, targeting the immunosuppressive molecule S...

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Detalles Bibliográficos
Autores principales: Manuel, Edwin R., Blache, Céline A., Ellenhorn, Joshua D.I., Diamond, Don J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377007/
https://www.ncbi.nlm.nih.gov/pubmed/22720256
http://dx.doi.org/10.4161/onci.1.2.18180
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author Manuel, Edwin R.
Blache, Céline A.
Ellenhorn, Joshua D.I.
Diamond, Don J.
author_facet Manuel, Edwin R.
Blache, Céline A.
Ellenhorn, Joshua D.I.
Diamond, Don J.
author_sort Manuel, Edwin R.
collection PubMed
description Improving on the limited success of cancer immunotherapy requires new approaches to inhibit immunosuppressive pathways initiated by tumor cells to “escape” protective immunity. One unique approach utilizes Salmonella for systemic delivery of inhibitory RNA, targeting the immunosuppressive molecule Stat3, and a Survivin vaccine to suppress growth of aggressive murine tumors.
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spelling pubmed-33770072012-06-20 Survivin the battle against immunosuppression Manuel, Edwin R. Blache, Céline A. Ellenhorn, Joshua D.I. Diamond, Don J. Oncoimmunology Author's View Improving on the limited success of cancer immunotherapy requires new approaches to inhibit immunosuppressive pathways initiated by tumor cells to “escape” protective immunity. One unique approach utilizes Salmonella for systemic delivery of inhibitory RNA, targeting the immunosuppressive molecule Stat3, and a Survivin vaccine to suppress growth of aggressive murine tumors. Landes Bioscience 2012-03-01 /pmc/articles/PMC3377007/ /pubmed/22720256 http://dx.doi.org/10.4161/onci.1.2.18180 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Manuel, Edwin R.
Blache, Céline A.
Ellenhorn, Joshua D.I.
Diamond, Don J.
Survivin the battle against immunosuppression
title Survivin the battle against immunosuppression
title_full Survivin the battle against immunosuppression
title_fullStr Survivin the battle against immunosuppression
title_full_unstemmed Survivin the battle against immunosuppression
title_short Survivin the battle against immunosuppression
title_sort survivin the battle against immunosuppression
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377007/
https://www.ncbi.nlm.nih.gov/pubmed/22720256
http://dx.doi.org/10.4161/onci.1.2.18180
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AT blachecelinea survivinthebattleagainstimmunosuppression
AT ellenhornjoshuadi survivinthebattleagainstimmunosuppression
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