Virus infections in tumors pave the way for tumor-directed DC-vaccines

Effective treatment of solid cancers by tumor-directed DC-vaccines still remains a challenge in clinical oncology. For therapeutic success, knock-down of tumor-specific tolerance appears mandatory before a potent tumor-specific cytotoxic T-cell response can be triggered by DC-vaccinations. Evidence...

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Detalles Bibliográficos
Autores principales: Woller, Norman, Kühnel, Florian, Kubicka, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377008/
https://www.ncbi.nlm.nih.gov/pubmed/22720244
http://dx.doi.org/10.4161/onci.1.2.18099
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author Woller, Norman
Kühnel, Florian
Kubicka, Stefan
author_facet Woller, Norman
Kühnel, Florian
Kubicka, Stefan
author_sort Woller, Norman
collection PubMed
description Effective treatment of solid cancers by tumor-directed DC-vaccines still remains a challenge in clinical oncology. For therapeutic success, knock-down of tumor-specific tolerance appears mandatory before a potent tumor-specific cytotoxic T-cell response can be triggered by DC-vaccinations. Evidence is emerging that lytic virus infection in tumors can provide valuable help.
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spelling pubmed-33770082012-06-20 Virus infections in tumors pave the way for tumor-directed DC-vaccines Woller, Norman Kühnel, Florian Kubicka, Stefan Oncoimmunology Author's View Effective treatment of solid cancers by tumor-directed DC-vaccines still remains a challenge in clinical oncology. For therapeutic success, knock-down of tumor-specific tolerance appears mandatory before a potent tumor-specific cytotoxic T-cell response can be triggered by DC-vaccinations. Evidence is emerging that lytic virus infection in tumors can provide valuable help. Landes Bioscience 2012-03-01 /pmc/articles/PMC3377008/ /pubmed/22720244 http://dx.doi.org/10.4161/onci.1.2.18099 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Woller, Norman
Kühnel, Florian
Kubicka, Stefan
Virus infections in tumors pave the way for tumor-directed DC-vaccines
title Virus infections in tumors pave the way for tumor-directed DC-vaccines
title_full Virus infections in tumors pave the way for tumor-directed DC-vaccines
title_fullStr Virus infections in tumors pave the way for tumor-directed DC-vaccines
title_full_unstemmed Virus infections in tumors pave the way for tumor-directed DC-vaccines
title_short Virus infections in tumors pave the way for tumor-directed DC-vaccines
title_sort virus infections in tumors pave the way for tumor-directed dc-vaccines
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377008/
https://www.ncbi.nlm.nih.gov/pubmed/22720244
http://dx.doi.org/10.4161/onci.1.2.18099
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