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UPDATE IN THE TREATMENT OF CUTANEOUS LEISHMANIASIS
BACKGROUND: Cutaneous leishmaniasis (CL) is still a major health problem in many countries including Saudi Arabia. Patients with CL are seen, not only by dermatologists, but also by pediatricians and community physicians. Knowledge of available treatment options is essential. DESIGN: A literature re...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377028/ https://www.ncbi.nlm.nih.gov/pubmed/23012189 |
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author | Al-Natour, Sahar H. |
author_facet | Al-Natour, Sahar H. |
author_sort | Al-Natour, Sahar H. |
collection | PubMed |
description | BACKGROUND: Cutaneous leishmaniasis (CL) is still a major health problem in many countries including Saudi Arabia. Patients with CL are seen, not only by dermatologists, but also by pediatricians and community physicians. Knowledge of available treatment options is essential. DESIGN: A literature review utilizing PubMed and Cochrane evidence-based library was undertaken in the last five years. RESULTS: Several medications and therapeutic modalities are currently in use, though the gold standard remains systemic antimonials. Drug resistance and serious side effects preclude the use of available medications. Newer therapies like liposomal amphotericin B, miltefosine and pentamidine are being used; while it is hoped that other drugs like imiquimod, tamoxifen, PDT and pentamidine structural analogs being tested would offer better efficacy, easier administration and lower toxicity. CONCLUSION: After decades of little advance in the treatment of leishmaniasis, there are now several options with newer compounds and combinations of these. |
format | Online Article Text |
id | pubmed-3377028 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-33770282012-09-24 UPDATE IN THE TREATMENT OF CUTANEOUS LEISHMANIASIS Al-Natour, Sahar H. J Family Community Med Review Article BACKGROUND: Cutaneous leishmaniasis (CL) is still a major health problem in many countries including Saudi Arabia. Patients with CL are seen, not only by dermatologists, but also by pediatricians and community physicians. Knowledge of available treatment options is essential. DESIGN: A literature review utilizing PubMed and Cochrane evidence-based library was undertaken in the last five years. RESULTS: Several medications and therapeutic modalities are currently in use, though the gold standard remains systemic antimonials. Drug resistance and serious side effects preclude the use of available medications. Newer therapies like liposomal amphotericin B, miltefosine and pentamidine are being used; while it is hoped that other drugs like imiquimod, tamoxifen, PDT and pentamidine structural analogs being tested would offer better efficacy, easier administration and lower toxicity. CONCLUSION: After decades of little advance in the treatment of leishmaniasis, there are now several options with newer compounds and combinations of these. Medknow Publications & Media Pvt Ltd 2009 /pmc/articles/PMC3377028/ /pubmed/23012189 Text en Copyright: © Journal of Family and Community Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Al-Natour, Sahar H. UPDATE IN THE TREATMENT OF CUTANEOUS LEISHMANIASIS |
title | UPDATE IN THE TREATMENT OF CUTANEOUS LEISHMANIASIS |
title_full | UPDATE IN THE TREATMENT OF CUTANEOUS LEISHMANIASIS |
title_fullStr | UPDATE IN THE TREATMENT OF CUTANEOUS LEISHMANIASIS |
title_full_unstemmed | UPDATE IN THE TREATMENT OF CUTANEOUS LEISHMANIASIS |
title_short | UPDATE IN THE TREATMENT OF CUTANEOUS LEISHMANIASIS |
title_sort | update in the treatment of cutaneous leishmaniasis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377028/ https://www.ncbi.nlm.nih.gov/pubmed/23012189 |
work_keys_str_mv | AT alnatoursaharh updateinthetreatmentofcutaneousleishmaniasis |