Ameliorative potential of Coccinia grandis extract on serum and liver marker enzymes and lipid profile in streptozotocin induced diabetic rats

Diabetes mellitus is the most severe metabolic pandemic of the 21(st) century, affecting essential biochemical activities in almost every cell in the body. Indian literatures have already mentioned herbal remediation for a number of human ailments. The present study was undertaken to evaluate the potential of Coccinia grandis extract on serum and liver marker enzymes (ALP, AST, ALT and LDH) and lipid profile (total cholesterol, phospholipids, triglycerides and free fatty acids in serum and liver) in streptozotocin induced diabetic animals. The experimental animals were treated with methanolic extract of Coccinia grandis and the levels of marker enzymes and lipid profile were estimated. The ALP, AST, ALT and LDH levels were increased in diabetic rats and restored to near normal levels after administration of plant extract. The lipid profile increased in diabetic group and after the treatment with the plant extract the levels were reverted to near normal. Thus the methanolic extract of Coccinia grandis has a potent ability to restore the marker enzymes and the lipid profile was reverted to near normal levels.