To live or to die: a matter of processing damaged DNA termini in neurons

Defects in the repair of deoxyribonucleic acid (DNA) damage underpin several hereditary neurological diseases in humans. Of the different activities that repair chromosomal DNA breaks, defects in resolving damaged DNA termini are among the most common causes of neuronal cell death. Here, the molecul...

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Detalles Bibliográficos
Autor principal: El-Khamisy, Sherif F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377058/
https://www.ncbi.nlm.nih.gov/pubmed/21246735
http://dx.doi.org/10.1002/emmm.201000114
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author El-Khamisy, Sherif F
author_facet El-Khamisy, Sherif F
author_sort El-Khamisy, Sherif F
collection PubMed
description Defects in the repair of deoxyribonucleic acid (DNA) damage underpin several hereditary neurological diseases in humans. Of the different activities that repair chromosomal DNA breaks, defects in resolving damaged DNA termini are among the most common causes of neuronal cell death. Here, the molecular mechanisms of some of the DNA end processing activities are reviewed and the association with human neurodegenerative disease is discussed.
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spelling pubmed-33770582012-09-17 To live or to die: a matter of processing damaged DNA termini in neurons El-Khamisy, Sherif F EMBO Mol Med Review Defects in the repair of deoxyribonucleic acid (DNA) damage underpin several hereditary neurological diseases in humans. Of the different activities that repair chromosomal DNA breaks, defects in resolving damaged DNA termini are among the most common causes of neuronal cell death. Here, the molecular mechanisms of some of the DNA end processing activities are reviewed and the association with human neurodegenerative disease is discussed. WILEY-VCH Verlag 2011-02 /pmc/articles/PMC3377058/ /pubmed/21246735 http://dx.doi.org/10.1002/emmm.201000114 Text en Copyright © 2011 EMBO Molecular Medicine
spellingShingle Review
El-Khamisy, Sherif F
To live or to die: a matter of processing damaged DNA termini in neurons
title To live or to die: a matter of processing damaged DNA termini in neurons
title_full To live or to die: a matter of processing damaged DNA termini in neurons
title_fullStr To live or to die: a matter of processing damaged DNA termini in neurons
title_full_unstemmed To live or to die: a matter of processing damaged DNA termini in neurons
title_short To live or to die: a matter of processing damaged DNA termini in neurons
title_sort to live or to die: a matter of processing damaged dna termini in neurons
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377058/
https://www.ncbi.nlm.nih.gov/pubmed/21246735
http://dx.doi.org/10.1002/emmm.201000114
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